To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model

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dc.authoridAltan, Ahmet/0000-0003-2041-6364
dc.contributor.authorArpag, Osman Fatih
dc.contributor.authorDamlar, Ibrahim
dc.contributor.authorAltan, Ahmet
dc.contributor.authorTatli, Ufuk
dc.contributor.authorGunay, Ahmet
dc.date.accessioned2024-09-18T20:26:52Z
dc.date.available2024-09-18T20:26:52Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAmong the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p<0.05). The volume of residual graft was significantly decreased in HA group compared to xenograft group (p=0.035). Marrow space, trabecular thickness (TbTh), trabecular width (TbWi), trabecular separation (TbSp), and number of node: number of terminus (NNd:NTm) in the autograft group were significantly better than xenograft and HA groups (p<0.05). However, regarding marrow space, TbTh, TbWi, TbSp, and NNd: NTm values, xenograft and HA groups showed similar results and the difference were not significant (p>0.05). Conclusion: These results support that high molecular weight hyaluronic acid could contribute to the healing of xenograft by improving the percentage of new bone formation and reducing the percentage of residual graft. However, HA did not significantly affect the quality of newly formed bone assessed by microarchitectural parameters.en_US
dc.description.sponsorshipScientific Research Projects Agency Coordination of Mustafa Kemal Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Agency Coordination of Mustafa Kemal University.en_US
dc.identifier.doi10.1590/1678-7757-2017-0004
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.pmid29364337en_US
dc.identifier.scopus2-s2.0-85040987978en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1590/1678-7757-2017-0004
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10575
dc.identifier.volume26en_US
dc.identifier.wosWOS:000423208400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo Fac Odontologia Bauruen_US
dc.relation.ispartofJournal of Applied Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyaluronic aciden_US
dc.subjectXenograften_US
dc.subjectHistological techniqueen_US
dc.subjectBone formationen_US
dc.titleTo what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit modelen_US
dc.typeArticleen_US

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