In vitro 5-fluorouracil release properties investigation from pH sensitive sodium alginate coated and uncoated methyl cellulose/chitosan microspheres

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dc.authoridOlukman Sahin, Merve/0000-0002-9588-2661
dc.contributor.authorOlukman Sahin, Merve
dc.contributor.authorSanli, Oya
dc.date.accessioned2024-09-18T19:47:58Z
dc.date.available2024-09-18T19:47:58Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstract5-Fluorouracil (5-FU) has been in clinical practice for decades one of the oldest chemotherapy agents. However, intravenous administration of 5-FU requires the development of an oral controlled delivery system for improved patient compliances. For this purpose, 5-FU loaded and sodium alginate (NaAlg) coated and uncoated methyl cellulose (MC)/chitosan (CS) microspheres were prepared by emulsion crosslinking method using a mixture of water and oil. Firstly, MC/CS microspheres were prepared and then coated with NaAlg. The prepared microspheres were characterized by optical microscopy, Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Microspheres were also characterized by equilibrium swelling values and drug release profiles. The in vitro drug release studies were carried out with three pH values 1.2, 6.8, and 7.4, respectively, each for 2 h. It was determined that coating the microspheres with NaAlg provides more controlled drug release, especially at pH 1.2. The effects of the preparation conditions, such as coating time, MC/CS ratio, NaAlg concentration, and crosslinker concentration on the 5-FU release were investigated.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Gazi University [05/2010-09]en_US
dc.description.sponsorshipThe authors are thankful to the Scientific Research Projects Coordination Unit of Gazi University [Project numbers: 05/2010-09] for their financial support. We will always remember the people who lost their lives at earthquake occurred on February 6 2023 in Turkiye.en_US
dc.identifier.doi10.1016/j.ijbiomac.2023.128895
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid38141696en_US
dc.identifier.scopus2-s2.0-85181114110en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.128895
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7259
dc.identifier.volume258en_US
dc.identifier.wosWOS:001150194300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5-fluorouracilen_US
dc.subjectAnticancer drugsen_US
dc.subjectMicrospheresen_US
dc.subjectControlled releaseen_US
dc.titleIn vitro 5-fluorouracil release properties investigation from pH sensitive sodium alginate coated and uncoated methyl cellulose/chitosan microspheresen_US
dc.typeArticleen_US

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