Acute Kidney Injury: Medical Causes and Pathogenesis

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dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.authoridAWAD, ALAA/0000-0002-4468-4446
dc.contributor.authorTurgut, Faruk
dc.contributor.authorAwad, Alaa S. S.
dc.contributor.authorAbdel-Rahman, Emaad M. M.
dc.date.accessioned2024-09-18T19:50:20Z
dc.date.available2024-09-18T19:50:20Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAcute kidney injury (AKI) is a common clinical syndrome characterized by a sudden decline in or loss of kidney function. AKI is not only associated with substantial morbidity and mortality but also with increased risk of chronic kidney disease (CKD). AKI is classically defined and staged based on serum creatinine concentration and urine output rates. The etiology of AKI is conceptually classified into three general categories: prerenal, intrarenal, and postrenal. Although this classification may be useful for establishing a differential diagnosis, AKI has mostly multifactorial, and pathophysiologic features that can be divided into different categories. Acute tubular necrosis, caused by either ischemia or nephrotoxicity, is common in the setting of AKI. The timely and accurate identification of AKI and a better understanding of the pathophysiological mechanisms that cause kidney dysfunction are essential. In this review, we consider various medical causes of AKI and summarize the most recent updates in the pathogenesis of AKI.en_US
dc.identifier.doi10.3390/jcm12010375
dc.identifier.issn2077-0383
dc.identifier.issue1en_US
dc.identifier.pmid36615175en_US
dc.identifier.scopus2-s2.0-85145554297en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm12010375
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7366
dc.identifier.volume12en_US
dc.identifier.wosWOS:000909014200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacute kidney injuryen_US
dc.subjectprerenal AKIen_US
dc.subjectacute tubular necrosisen_US
dc.subjectacute interstitial nephritisen_US
dc.subjectacute glomerulonephritisen_US
dc.subjectpostrenal AKIen_US
dc.titleAcute Kidney Injury: Medical Causes and Pathogenesisen_US
dc.typeReview Articleen_US

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