Effects of trimetazidine on crush injury of the sciatic nerve in rats: A biochemical and stereological study

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dc.authoridBal, Ramazan/0000-0003-3829-8669
dc.authoridkeles, osman nuri/0000-0001-7740-8248
dc.contributor.authorSerayslan, Yurdal
dc.contributor.authorBal, Ramazan
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorKontas, Tuenay
dc.contributor.authorKeles, Osman Nuri
dc.contributor.authorUnal, Deniz
dc.contributor.authorUnal, Bunyami
dc.date.accessioned2024-09-18T21:00:24Z
dc.date.available2024-09-18T21:00:24Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTrimetazidine (TMZ) is an anti-ischemic agent which has been used for years as an effective anti-anginal agent in cardiac patients. The aim of the study was to investigate the effect of TMZ on the level of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), catalase (CAT), histopathological changes and the number of myelinated axons in a crush injury model of sciatic nerve in rats. In this study, 50 Wistar albino rats were used and the right sciatic nerves of all animals were injured. They were randomly divided into two groups equal in number, called treatment and non-treatment groups. The animals were subdivided into four subgroups, non-injury/non-treatment (left sciatic nerves of non-treatment animals, NI-NT) and non-injury/treatment (left sciatic nerves of treatment animals, NI-T) and injury/non-treatment (right sciatic nerves of non-treatment animals, I-NT) and injury/ treatment (right sciatic nerves of treatment animals, I-T). At the end of the experiment, the bilateral sciatic nerves and blood samples collected from these animals were analyzed using histological, stereological and biochemical methods. There was a progressive increase in the serum level of GSH and progressive decrease in serum MDA levels in the treatment group. Progressive decrease in serum NO levels was observed in the treatment groups and it was statistically significant on day 14 (p<0.05) compared to the non-treatment group. The activities of CAT were low in the treatment groups on days 21 (p < 0.05) and 42 (p < 0.05). In the NI-NT group, some unimportant degenerative changes such as irregularity in myelin sheets were observed. Many pathologic changes in the I-NT group and some minimal degeneration in the I-T group were observed. TMZ treatment resulted in increases in the myelinated axon numbers by a range of 223 to 604 in the I-NT group compared to the I-T. In conclusion, TMZ appears to be beneficial for induction of axonal regeneration and myelination in healthy nerves as well as injured nerves. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2008.10.007
dc.identifier.endpage20en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid18983835en_US
dc.identifier.scopus2-s2.0-57349098306en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2008.10.007
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12653
dc.identifier.volume1247en_US
dc.identifier.wosWOS:000262925700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrimetazidineen_US
dc.subjectInjuryen_US
dc.subjectStereologyen_US
dc.subjectMyelin sheathen_US
dc.subjectNerve injuryen_US
dc.subjectHistopathologyen_US
dc.subjectSciatic nerveen_US
dc.titleEffects of trimetazidine on crush injury of the sciatic nerve in rats: A biochemical and stereological studyen_US
dc.typeArticleen_US

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