Eucalyptol alleviates cisplatin-induced kidney damage in rats

Basit Öğe Kaydı
dc.authoridKazak, Filiz/0000-0002-9065-394X
dc.authoridAkcakavak, Gokhan/0000-0001-5949-4752
dc.contributor.authorKazak, Filiz
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.contributor.authorAkcakavak, Goekhan
dc.date.accessioned2024-09-18T19:54:38Z
dc.date.available2024-09-18T19:54:38Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was aimed to explore the therapeutic effect of eucalyptol on cisplatin induced kidney damage in Wistar albino rats. The animals were divided into four groups: sham (S), eucalyptol (E), cisplatin (C), and cisplatin + eucalyptol (CE) randomly, six animals in each group. Groups C and CE were received cisplatin (12 mg/kg, a single dose, intraperitoneally (i.p.)). Groups E and CE were treated with eucalyptol (100 mg/kg, for seven days, orally). The blood samples and kidney tissues were collected following sacrification and analyzed histopathologically and biochemically. Histopathological results revealed tubular degeneration and necrosis, inflammatory cell infiltration, tubular lumen dilatation, enlargement of bowman's space and hyaline cast were significantly irregular in the group C than group S. However, eucalyptol treatment (CE) modulated the alterations in the group C. Serum levels of blood urea nitrogen (BUN) and creatinine (CRE) were considerably higher in the group C compared to the other groups. There was no significant difference among the other groups statistically (except group C) in terms of BUN and CRE values. Eucalyptol treatment (at 100 mg/kg, for seven days) decreased the cisplatin induced increase in serum BUN and CRE levels and restored the reduced Vit C level and CAT activity of kidneys caused by cisplatin. Thus, eucalyptol's antioxidative, nephroprotective, and curative effects indicated the potential for future drug development.en_US
dc.identifier.doi10.1080/01480545.2022.2156530
dc.identifier.endpage179en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2en_US
dc.identifier.pmid36514998en_US
dc.identifier.scopus2-s2.0-85144067083en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage172en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2022.2156530
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7835
dc.identifier.volume47en_US
dc.identifier.wosWOS:000897205300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectcisplatinen_US
dc.subjecteucalyptolen_US
dc.subjectkidneyen_US
dc.subjectnephrotoxicityen_US
dc.titleEucalyptol alleviates cisplatin-induced kidney damage in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7835.pdf
Boyut:
1.73 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu