Systemic and ocular determinants of mean ocular perfusion pressure in a population-based sample

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dc.authoridYildirim, Nilgun/0000-0001-6266-4951
dc.authoridAtalay, Eray/0000-0002-2536-4279
dc.contributor.authorCakmak, Ayse Idil
dc.contributor.authorAtalay, Eray
dc.contributor.authorGultekin Irgat, Saadet
dc.contributor.authorKoktas, Zulfiye
dc.contributor.authorYildirim, Nilgun
dc.date.accessioned2024-09-18T20:52:50Z
dc.date.available2024-09-18T20:52:50Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose To investigate the associations between mean ocular perfusion pressure (MOPP) and several variables including body mass index (BMI), comorbid medical conditions and various ocular parameters in a population-based sample. Study design Cross-sectional. Methods Data of 2091 healthy participants from a previous population based cross-sectional study were reviewed. Inclusion criteria were adults >= 40 years of age who were screened on-site for glaucoma. Data on medical history, height, weight, systolic and diastolic blood pressures (SBP and DBP, respectively) were obtained. A basic ocular examination was performed which included intraocular pressure (Tono-Pen XL, Reichert Technologies) and central corneal thickness (Pacline pachymetry;) measurement, slit-lamp examination and non-mydriatic optic disc photography (nonmyd alpha fundus camera, Kowa). MOPP was calculated using the formula [2/3 x (DBP + 1/3(SBP-DBP)]-IOP and low MOPP was defined as MOPP <= 45 mmHg. Results Mean age of the subjects was 63.04 +/- 9.7 years (range: 44 and 99 years) and the majority were women (74.1%, n = 1549). Mean MOPP values in normal weight (BMI < 25), overweight (BMI = 25-29.9) and in obese individuals were 46.9 +/- 9.0 mmHg, 48.6 +/- 9.2 mmHg and 50.7 +/- 10.0 mmHg, respectively (p < 0.001, in all pairwise comparisons). In the multivariable logistic regression analysis, migraine and IOP elevation (per 1 mmHg increment) were significantly associated with a low MOPP (OR: 2.10 and 1.22, p = 0.008 and < 0.001, respectively). On the other hand, risk of low MOPP was reduced in subjects with hypertension, and with increasing age (per 1-year increment) and BMI (per 1-unit increment) (OR: 0.15, 0.97, and 0.95, respectively, and p < 0.001 for all). Conclusion Migraine and elevated IOP increase the risk of low MOPP and this may have a causal relationship with impaired optic nerve head blood flow.en_US
dc.identifier.doi10.1007/s10384-020-00728-1
dc.identifier.endpage397en_US
dc.identifier.issn0021-5155
dc.identifier.issn1613-2246
dc.identifier.issue4en_US
dc.identifier.pmid32112186en_US
dc.identifier.scopus2-s2.0-85081229569en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage392en_US
dc.identifier.urihttps://doi.org/10.1007/s10384-020-00728-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11437
dc.identifier.volume64en_US
dc.identifier.wosWOS:000516997400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJapanese Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOcular perfusion pressureen_US
dc.subjectObesityen_US
dc.subjectMigraineen_US
dc.subjectGlaucomaen_US
dc.subjectHypertensionen_US
dc.titleSystemic and ocular determinants of mean ocular perfusion pressure in a population-based sampleen_US
dc.typeArticleen_US

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