The expression levels of the sirtuins in patients with BCC

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dc.authoridtemel, metin/0000-0002-1829-9894
dc.contributor.authorTemel, Metin
dc.contributor.authorKoc, Mustafa Nihat
dc.contributor.authorUlutas, Saffet
dc.contributor.authorGogebakan, Bulent
dc.date.accessioned2024-09-18T20:04:21Z
dc.date.available2024-09-18T20:04:21Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBasal cell carcinoma (BCC) is the most common tumor in humans. Reduced expression of sirtuins interferes with DNA repair, which may cause mutations and genomic instability, and eventually leads to tumor development. In the present study, we investigate the expression levels of SIRT genes in non-tumoral and tumor tissues of patients with BCC. A total of 27 patients (16 males, 11 females) with BCC were included in the study; the mean age was 65.40 +/- 10.74 years and mean follow-up was 2.5 +/- 0.5 years. There were multiple synchronous lesions in six patients, and the remaining 21 patients had a single lesion. Tumor and nontumoral tissue samples were collected from all patients, and mRNA expression levels of SIRT1-7 (Sirt1.1, Sirt1.2, Sirt2, Sirt3, Sirt4, Sirt5, Sirt6, and Sirt7) were examined by real-time PCR. The results showed that expressions of SIRT1.1, SIRT1.2, SIRT4, SIRT5, SIRT6, and SIRT7 mRNAs were unchanged in tumor tissues of BCC patients compared with non-tumoral tissue samples. Importantly, the expressions of SIRT2 and SIRT3 mRNAs were significantly reduced in tumor tissue samples from BCC patients compared with non-tumoral tissues (P=0.02 and P=0.03, respectively). In light of the previous reports that have demonstrated a link between SIRT proteins and cancer, our findings suggest that SIRT2 and SIRT3 may plan important roles in BCC pathogenesis and could be candidate prognostic biomarkers for BCC.en_US
dc.identifier.doi10.1007/s13277-015-4522-8
dc.identifier.endpage6435en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue5en_US
dc.identifier.pmid26631040en_US
dc.identifier.scopus2-s2.0-84948961036en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6429en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-015-4522-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8095
dc.identifier.volume37en_US
dc.identifier.wosWOS:000376465800086en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBCCen_US
dc.subjectSirtuinen_US
dc.subjectSIRTen_US
dc.subjectCanceren_US
dc.subjectLifespanen_US
dc.subjectLongevityen_US
dc.titleThe expression levels of the sirtuins in patients with BCCen_US
dc.typeArticleen_US

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