Use of an antiarrhythmic drug against acute selenium toxicity

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dc.authoridkomuroglu, ahmet ufuk/0000-0002-0371-9251
dc.authoridmercan yucel, ufuk/0000-0001-8256-7868
dc.contributor.authorYucel, Ufuk Mercan
dc.contributor.authorBasbugan, Yildiray
dc.contributor.authorUyar, Ahmet
dc.contributor.authorKomuroglu, Ahmet Ufuk
dc.contributor.authorKeles, Omer Faruk
dc.date.accessioned2024-09-18T20:56:54Z
dc.date.available2024-09-18T20:56:54Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Selenium is an essential trace element. But, selenium may have toxic effects in high doses. There are no proven antidotes or curative treatments for acut selenium toxicity. Treatment involves stopping the exposure and providing supportive care for symptoms. Therefore, it is necessary to find more effective substances in the treatment of selenium toxicity. The aim of this study was to increase the survival rate of animals by supporting the heart with amiodarone and to determine the effect of amiodarone on the pathological, hematological and biochemical parameters in acute selenium intoxication. Methods: 64 Wistar-Albino rats were divided into four groups. Group I was given only distilled water, Group II was given 18 mg/kg dose of amiodarone, Group III was given 18 mg/kg amiodarone and 10 mg/kg sodium selenite and Group IV was given sodium selenite 10 mg/kg (LD50 dose)orally. Results: 11 of the 16 animals in Group IV died within the first 48 h of drug administration. However, no deaths were observed in the rats in Group III. No hematological changes were observed. Biochemically, CK, CK-MB and LDH levels of Group IV were higher than the other groups on both the 2nd and 10th days. In Groups II and III, this serum level decreased, and vitamin B12 levels increased. In macroscopic inspections of the organs of Groups III and IV, slight paleness was detected. Histopathologically, degenerative changes in tissue were observed, especially in Group IV. Conclusion: This study shows that amiodarone application has a reducing effect on selenium toxicity. This was because amiodarone protected the heart by reducing CK and CK-MB levels and increased vitamin B12 levels, which play a role in the synthesis of S-adenosyl methionine that converts selenium into a nontoxic form.en_US
dc.identifier.doi10.1016/j.jtemb.2020.126471
dc.identifier.issn0946-672X
dc.identifier.pmid32032907en_US
dc.identifier.scopus2-s2.0-85078813383en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2020.126471
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12169
dc.identifier.volume59en_US
dc.identifier.wosWOS:000524412400019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal of Trace Elements in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSeleniumen_US
dc.subjectAmiodaroneen_US
dc.subjectAcute toxicityen_US
dc.subjectSurvival rateen_US
dc.titleUse of an antiarrhythmic drug against acute selenium toxicityen_US
dc.typeArticleen_US

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