Effects of a Single Dose of Topical Brimonidine 0.15% on Anterior Segment Morphology, Pupil Characteristics, and Choroidal Thickness in Healthy Subjects

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dc.authoridTEKIN, KEMAL/0000-0002-7461-6129
dc.contributor.authorCankurtaran, Veysel
dc.contributor.authorTekin, Kemal
dc.date.accessioned2024-09-18T20:06:13Z
dc.date.available2024-09-18T20:06:13Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To investigate the effects of a single dose of brimonidine 0.15% on anterior segment morphology, pupil characteristics, and choroidal blood flow in treated and untreated eyes of healthy subjects and to compare the results obtained with those in another healthy volunteer group. Methods: Participants were classified as study and control groups. The eyes in the study group were randomized. Only one eye received one drop of brimonidine (treated eyes), and the contralateral eye received single dose of sodium hyaluronate (untreated eyes). In addition, only right eyes of control subjects, who had single dose of sodium hyaluronate to both eyes, were analyzed (control eyes). Anterior segment parameters including central corneal thickness (CCT), aqueous depth, anterior chamber volume, iridocorneal angle (ICA), horizontal anterior chamber diameter, and pupil measurements including scotopic, mesopic, photopic, and dynamic pupil diameters (PDs) were performed with Sirius Scheimpflug camera. Choroidal thickness (CT) measurements were taken with optical coherence tomography. These measurements were taken at baseline and repeated 1 hour after the dosing. Results: Only the treated eyes had significantly thicker CCT and wider ICA values after instillation of brimonidine. Static and dynamic PD values of treated eyes and even untreated eyes significantly decreased after brimonidine. However, brimonidine has no significant effect on CT measurements. Conclusion: A single dose of brimonidine causes thickening in CCT and widening in ICA values in treated eyes. In addition, it has significant effect to decrease the scotopic, mesopic, photopic, and dynamic PD values in treated and even contralateral eyes while has no effect on choroidal blood flow.en_US
dc.identifier.doi10.1097/ICL.0000000000000708
dc.identifier.endpage329en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue6en_US
dc.identifier.pmid32443008en_US
dc.identifier.scopus2-s2.0-85106553709en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000000708
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8389
dc.identifier.volume47en_US
dc.identifier.wosWOS:000711669400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrimonidineen_US
dc.subjectCentral corneal thicknessen_US
dc.subjectChoroiden_US
dc.subjectIridocorneal angleen_US
dc.subjectPupilen_US
dc.titleEffects of a Single Dose of Topical Brimonidine 0.15% on Anterior Segment Morphology, Pupil Characteristics, and Choroidal Thickness in Healthy Subjectsen_US
dc.typeArticleen_US

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