The scintigraphic evaluation and genetic correlation of joint involvements in pediatric patients with familial Mediterranean fever

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dc.contributor.authorAydogan, F.
dc.contributor.authorTutanc, M.
dc.contributor.authorArica, V.
dc.contributor.authorArica, S.
dc.contributor.authorGunesacar, R.
dc.date.accessioned2024-09-18T20:04:40Z
dc.date.available2024-09-18T20:04:40Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: We aimed to evaluate the articular involvements in pediatric patients with familial Mediterranean fever (FM F) with joint symptoms by bone scintigraphy and to correlate the involved joints with the gene mutations. Materials and methods: A total of 41 newly diagnosed patients in pediatric age group (28 girls and 13 boys; mean age 9.14 +/- 2.91 years) with joint involvement symptoms were included in this study. Scintigraphic images were obtained at 5th min (blood pool or early phase) and starting at 3 h (late phase) after (after tracer injection) intravenous administration of technetium-99m (99mTc)-methylendiphosphonate (MDP). Genomic DNA was isolated from leukocytes using standard salting out procedure. The sequencing data were analyzed. Results: Of the 41 patients, arthritis was found in 21 (51.2%) patients. Of the 21 patients, there was single joint involvement in 15 (71.4%) patients and multiple joint involvement in six (28.6%) patients. The mean age of patients with joint involvement (8 +/- 2.3 years) were considerably lower than the patients without joint involvement (10.35 +/- 3.04 years), and this was statistically significant (p = 0.008). The most commonly involved joints were ankles and knees. Multiple joint involvements were most frequently observed in the M694V and M694I gene mutations (1 6.7%). Conclusions: We use and recommend the bone scintigraphy in patients with FMF to determine the presence and distribution of arthritis, since bone scintigraphy is inexpensive, noninvasive, easy-to-use, and also is more sensitive in the diagnosis and distribution of arthritis than conventional radiological methods and clinical examination.en_US
dc.identifier.doi10.1177/0960327112464797
dc.identifier.endpage343en_US
dc.identifier.issn0960-3271
dc.identifier.issue4en_US
dc.identifier.pmid23155201en_US
dc.identifier.scopus2-s2.0-84876725822en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1177/0960327112464797
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8302
dc.identifier.volume32en_US
dc.identifier.wosWOS:000317806000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone scintigraphyen_US
dc.subjectFMFen_US
dc.subjectgenetic analysisen_US
dc.titleThe scintigraphic evaluation and genetic correlation of joint involvements in pediatric patients with familial Mediterranean feveren_US
dc.typeArticleen_US

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