Comparison of the effects of bupivacaine, lidocaine, and tramadol infiltration on wound healing in rats

Basit Öğe Kaydı
dc.authorscopusid35240222100
dc.authorscopusid35317395700
dc.authorscopusid6508341312
dc.authorscopusid14319011400
dc.authorscopusid36571022900
dc.authorscopusid6701347162
dc.authorscopusid25645487000
dc.contributor.authorHanci, Volkan
dc.contributor.authorHakimo?lu, Sedat
dc.contributor.authorÖzaçmak, Haktan
dc.contributor.authorBektaş, Sibel
dc.contributor.authorÖzaçmak, Hale Sayan
dc.contributor.authorÖzdamar, Şükrü O?uz
dc.contributor.authorYurtlu, Serhan
dc.date.accessioned2024-09-19T15:43:29Z
dc.date.available2024-09-19T15:43:29Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and objectives: The aim of this study was to investigate the effects of saline solution, bupivacaine, lidocaine and tramadol infiltration on wound healing in rats. Method: Thirty-two male Wistar Albino rats were randomly separated into four groups, receiving 3. mL saline solution in control group (Group C, n = 8), 3. mL of 2% lidocaine in lidocaine group (Group L, n = 8), 3. mL of 0.5% bupivacaine in bupivacaine group (Group B, n = 8), and 3. mL of 5% tramadol in tramadol group (Group T, n = 8). Breaking-strength measurements, collagen bundle counting, and histopathologic evaluation were evaluated in the tissue samples taken from the rats. Results: Comparing the control group with the groups where bupivacaine and lidocaine were used for wound infiltration, collagen production was lower, breaking-strength measurements showed reduced resistance while significantly high edema, vascularity, inflammation scores were found (p < 0.0125). Between the control and the tramadol group there were no significant differences in collagen production, breaking-strength measurements, and edema, vascularity, inflammation scores (p > 0.0125). Conclusion: In our study, we found bupivacaine and lidocaine reduced the collagen production, wound breaking strength, and caused significantly high scores for edema, vascularity, and inflammation when compared to the control group. There was no significant difference between the control and the tramadol group. Results of this experimental preliminary study on rats support the idea that tramadol can be used for wound infiltration anesthesia without adverse effect on the surgical healing process. These results need to be verified in humans. © 2012 Elsevier Editora Ltda.en_US
dc.identifier.doi10.1016/S0034-7094(12)70180-0
dc.identifier.endpage810en_US
dc.identifier.issn1806-907X
dc.identifier.issue6en_US
dc.identifier.pmid23176988en_US
dc.identifier.scopus2-s2.0-84869763569en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage799en_US
dc.identifier.urihttps://doi.org/10.1016/S0034-7094(12)70180-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14354
dc.identifier.volume62en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofRevista Brasileira de Anestesiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnesthesia, Localen_US
dc.subjectBupivacaineen_US
dc.subjectLidocaineen_US
dc.subjectTramadolen_US
dc.subjectWound Healingen_US
dc.titleComparison of the effects of bupivacaine, lidocaine, and tramadol infiltration on wound healing in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
2.44 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu