Anticonvulsive and behavior modulating effects of sophoretin and rutoside

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dc.authoridDemir, Enver/0000-0002-2620-6192
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorOzturk, Atakan
dc.contributor.authorTutuk, Okan
dc.contributor.authorDogan, Hatice
dc.contributor.authorTumer, Cemil
dc.date.accessioned2024-09-18T20:56:54Z
dc.date.available2024-09-18T20:56:54Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Seizures are the hallmarks of most types of epilepsies. Behavioral and cognitive impairments coincide with interictal periods even though it is not clear whether these impairments spring out of the seizure itself or accompanying sociopsychological burden of the disease. Materials and methods: In this study, we investigated behavioral and cognitive consequences of a single GABA receptor-related seizure in mice, and examined the potential anticonvulsive and behavior-modulating properties of sophoretin (quercetin) and rutoside (rutin). Results: The study demonstrated that sophoretin and rutoside, common flavonoids of the human diet, delay the seizure onset and reduce the seizure stage. Moreover, they exerted an antidepressant-like effect, which was independent of the seizure. Neither treatments nor seizure altered recognition and spatial memory performances of the mice. Conclusions: Behavioral or cognitive disturbances that are evident in epileptic patients did not appear following a single seizure. In addition, we suggest that both sophoretin and rutoside successfully alleviate the seizure severity without interfering in the behavioral stability and cognitive performance. Hence, these flavonoids may be of use as adjuncts to the current treatment options.en_US
dc.identifier.doi10.1556/019.70.2019.29
dc.identifier.endpage259en_US
dc.identifier.issn2676-8615
dc.identifier.issn2676-8607
dc.identifier.issue3en_US
dc.identifier.pmid34554444en_US
dc.identifier.scopus2-s2.0-85078063444en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.1556/019.70.2019.29
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12168
dc.identifier.volume70en_US
dc.identifier.wosWOS:000509671500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofBiologia Futuraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectseizuresen_US
dc.subjectsophoretinen_US
dc.subjectrutosideen_US
dc.subjectquercetinen_US
dc.subjectrutinen_US
dc.subjectbehavioren_US
dc.titleAnticonvulsive and behavior modulating effects of sophoretin and rutosideen_US
dc.typeArticleen_US

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