Neuroprotective effect of alpha-lipoic acid and methylprednisolone on the spinal cord ischemia/reperfusion injury in rabbits

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dc.authoridKaravelioglu, Ergun/0000-0002-6611-1032
dc.contributor.authorBoyaci, Mehmet Gazi
dc.contributor.authorEser, Olcay
dc.contributor.authorKocogullari, Cevdet Ugur
dc.contributor.authorKaravelioglu, Ergun
dc.contributor.authorTokyol, Cigdem
dc.contributor.authorCan, Yesim
dc.date.accessioned2024-09-18T19:52:39Z
dc.date.available2024-09-18T19:52:39Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective. The aim of this study is to investigate the putative neuroprotective effect of alpha-lipoic acid (LA) on spinal ischemia/reperfusion (I/R) injury in rabbits. Methods. Thirty-five adult female New Zeland rabbits, weighing 2,000-3,500 g (mean: 2,800), were divided randomly into five groups of seven rabbits each (n: 7) as Group 1: sham, only laparotomy; Group 2 (i/R): I/R; Group 3 (LA): I/R and 100 mg/kg of LA; Group 4 (MP): I/R and 30 mg/kg of methylprednisolone (MP); and Group 5 (LA + MP): I/R and 100 mg/kg of LA plus 30 mg/kg of MP. Results. A statically significant effect of LA, MP, and LA plus MP on lowering malondialdehyde levels both in the blood and in the cerebrospinal fluid (CSF) has been observed. Nitric oxide is significantly decreased in the blood and spinal cord tissues, and also in the CSF but it is not significant. Superoxide dismutase, catalase, and glutathione levels were increased by LA administration. Conclusion. LA exhibits antioxidant efficacy in spinal cord I/R injury, but it cannot decrease the oxidative stress. The histopathological result of the present study also demonstrated that LA has neuroprotective effect in spinal cord injury.en_US
dc.identifier.doi10.3109/02688697.2014.954986
dc.identifier.endpage51en_US
dc.identifier.issn0268-8697
dc.identifier.issn1360-046X
dc.identifier.issue1en_US
dc.identifier.pmid25192009en_US
dc.identifier.scopus2-s2.0-84946015815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.3109/02688697.2014.954986
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7577
dc.identifier.volume29en_US
dc.identifier.wosWOS:000351644900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBritish Journal of Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha-lipoic aciden_US
dc.subjectischernia/reperfusionen_US
dc.subjectrabbiten_US
dc.subjectspinal corden_US
dc.titleNeuroprotective effect of alpha-lipoic acid and methylprednisolone on the spinal cord ischemia/reperfusion injury in rabbitsen_US
dc.typeArticleen_US

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