Curcumin as a Potential Therapeutic Agent for Mitigating Carbon Monoxide Poisoning: Evidence from an Experimental Rat Study

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dc.contributor.authorDogan, Guvenc
dc.contributor.authorKayir, Selcuk
dc.contributor.authorAyaz, Ercan
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorEkici, Arzu Akdagli
dc.date.accessioned2024-09-18T20:06:30Z
dc.date.available2024-09-18T20:06:30Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Carbon monoxide (CO) is a poisonous gas and causes tissue damage through oxidative stress. We aimed to investigate the protective value of curcumin in CO poisoning. Material/Methods: Twenty-four female Spraque Dawley rats were divided into 4 subgroups: controls (n=6), curcumin group (n=6), CO group (n=6), and curcumin+CO group (n=6). The experimental group was exposed to 3 L/min of CO gas at 3000 ppm. Curcumin was administered intraperitoneally at a dosage of 50 mg/kg. Hippocampal tissues were removed and separated for biochemical and immunohistochemical analysis. Tissue malondialdehyde (MDA) levels, nitric oxide (NO) levels, and superoxide dismutase (SOD) and catalase (CAT) activities were assayed spectrophotometrically, and serum asymmetric dimethylarginine (ADMA) were measured using the ELISA technique. Tissue Bcl-2 levels were detected by the immunohistochemistry method. Results: Tissue CAT and SOD activities and NO levels were significantly lower, and MDA and serum ADMA levels were higher in the CO group than in the control group ( P <0.001). The curcumin+CO group had higher CAT activities ( P =0.007) and lower MDA than the CO group ( P <0.001) and higher ADMA levels than the control group ( P =0.023). However, there was no significant difference observed for tissue SOD activity or NO levels between these 2 groups. In the curcumin+CO group, the Bcl-2 level was higher than that in the CO group ( P =0.017). Conclusions: The positive effect of curcumin on CAT activities, together with suppression of MDA levels, has shown that curcumin may have a protective effect against CO poisoning.en_US
dc.identifier.doi10.12659/MSM.943739
dc.identifier.issn1643-3750
dc.identifier.pmid38896554en_US
dc.identifier.scopus2-s2.0-85196679786en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.943739
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8555
dc.identifier.volume30en_US
dc.identifier.wosWOS:001257148000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbon Monoxideen_US
dc.subjectNeuroprotective Agentsen_US
dc.subjectCurcuminen_US
dc.subjectCarbon Monoxide Poisoningen_US
dc.titleCurcumin as a Potential Therapeutic Agent for Mitigating Carbon Monoxide Poisoning: Evidence from an Experimental Rat Studyen_US
dc.typeArticleen_US

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