Effect of Serum Gamma-Glutamyl Transferase Levels on Myocardial Perfusion and Long-Term Prognosis After Primary Angioplasty in Patients With Acute ST-Elevation Myocardial Infarction

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dc.authoridOzcan, Firat/0000-0002-7954-7839
dc.authoridYAZICI, Huseyin/0000-0002-0996-0054
dc.contributor.authorOzcan, Firat
dc.contributor.authorKarakas, Mehmet Fatih
dc.contributor.authorOzlu, Mehmet Fatih
dc.contributor.authorAkcay, Adnan Burak
dc.contributor.authorBuyukkaya, Eyup
dc.contributor.authorKurt, Mustafa
dc.contributor.authorErden, Gonul
dc.date.accessioned2024-09-18T20:25:16Z
dc.date.available2024-09-18T20:25:16Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Gamma-glutamyl transferase (GGT) level was found to be elevated in plasma of patients with cardiovascular risk factors. The aim of our study was to assess the relationship between serum GGT levels and the occurrence of no-reflow as well as to evaluate the prognostic value of GGT in ST-segment elevation myocardial infarction (STEMI) population. Methods and Results: One hundred sixty-eight consecutive patients with STEMI who underwent percutaneous coronary intervention (PCI) were enrolled in the study. Patients with STEMI were grouped into tertiles according to their admission serum GGT levels. No-reflow after PCI was assessed both angiographically (thrombolysis in myocardial infarction [TIMI] flow and myocardial blush grade) and electrocardiographically (ST resolution). Gamma-glutamyl transferase levels were higher in patients with STEMI compared to the elective PCI group subjects. Patients with angiographically (TIMI flow <= 2 or TIMI flow 3 with final myocardial bush grade <= 2 after PCI) and electrocardiographically (ST resolution <30%) detected no-reflow were increased in number across the GGT tertiles. In addition, 1-year mortality rates showed a significant increase across the tertile groups (4% vs 11% vs 23%, P<0.01). Multivariable logistic regression analysis revealed that GGT levels on admission were a significant predictor of long-term mortality of myocardial blush grade-detected no-reflow phenomenon. High GGT level on admission was a significant predictor for long-term mortality and major adverse cardiac events. Conclusions: In patients with STEMI undergoing primary PCI, high GGT levels at admission were found to be associated with no-reflow phenomenon and increased long-term mortality.en_US
dc.identifier.doi10.2310/JIM.0b013e31826d9043
dc.identifier.endpage1193en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue8en_US
dc.identifier.pmid23076164en_US
dc.identifier.scopus2-s2.0-84873654560en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1186en_US
dc.identifier.urihttps://doi.org/10.2310/JIM.0b013e31826d9043
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10208
dc.identifier.volume60en_US
dc.identifier.wosWOS:000311430500024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgamma-glutamyl transferaseen_US
dc.subjectST-segment elevation myocardial infarctionen_US
dc.subjectno-reflowen_US
dc.subjectmortalityen_US
dc.subjectprimary percutaneous coronary interventionen_US
dc.titleEffect of Serum Gamma-Glutamyl Transferase Levels on Myocardial Perfusion and Long-Term Prognosis After Primary Angioplasty in Patients With Acute ST-Elevation Myocardial Infarctionen_US
dc.typeArticleen_US

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