Comparison of triptans, NSAID and combination in migraine attack treatment

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.authoridSeydaoglu, Gulsah/0000-0002-0899-894X
dc.contributor.authorDuman, Taskin
dc.contributor.authorDede, Hava Ozlem
dc.contributor.authorSeydaoglu, Gulsah
dc.date.accessioned2024-09-18T20:02:45Z
dc.date.available2024-09-18T20:02:45Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: Headache during migraine attack may recur during a single attack. The present study evaluated efficacy of both individual and combined use of agents from nonsteroidal anti-inflammatory drug (NSAID) and triptan groups widely used in treatment of migraine attacks. Methods: A total of 201 attacks in 67 migraine patients were evaluated. Patients were divided into 3 study groups: those receiving rizatriptan 10mg, tenoxicam 20 mg, and rizatriptan + tenoxicam (combination). Patients evaluated severity of headache based on visual analogue scale (VAS) at moment of drug delivery, after 30 minutes, and after 1, 2, 4, 8 and 24 hours. Attacks were evaluated separately for each treatment alternative, and results were also compared. Results: VAS values were the same at onset of attack, but were lower in rizatriptan and combination groups than in tenoxicam group at 30 minutes and onward. VAS score was above 4 at 60 minutes in tenoxicam group and mean VAS value in this group was found to be significantly higher than values in rizatriptan and combined groups. At 24 hours, VAS scores were similar in combination and tenoxicam groups, while rizatriptan group had higher mean VAS score than the other 2 groups. Conclusion: When single drug use fails to provide adequate control, combined use of a rapid-acting triptan and a long-acting NSAID appears to be a suitable treatment option.en_US
dc.identifier.doi10.5505/agri.2015.00483
dc.identifier.endpage149en_US
dc.identifier.issn1300-0012
dc.identifier.issue3en_US
dc.identifier.pmid27813032en_US
dc.identifier.scopus2-s2.0-84980410199en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.5505/agri.2015.00483
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8001
dc.identifier.volume28en_US
dc.identifier.wosWOS:000382646100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofAgri-The Journal of The Turkish Society of Algologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAttacken_US
dc.subjectmigraineen_US
dc.subjectNSAIDen_US
dc.subjecttreatmenten_US
dc.subjecttriptanen_US
dc.titleComparison of triptans, NSAID and combination in migraine attack treatmenten_US
dc.typeArticleen_US

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