The cell fate: senescence or quiescence

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dc.authoridTerzi, Menderes Yusuf/0000-0001-8478-0451
dc.authoridIzmirli, Muzeyyen/0000-0002-8545-863X
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorIzmirli, Muzeyyen
dc.contributor.authorGogebakan, Bulent
dc.date.accessioned2024-09-18T20:56:55Z
dc.date.available2024-09-18T20:56:55Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSenescence and quiescence are frequently used as interchangeable terms in the literature unwittingly. Despite the fact that common molecules play role in decision of cell cycle arrest, senescent and quiescent cells have some distinctive phenotypes at both molecular and morphological levels. Thus, in this review we summarized the features of senescence and quiescence with respect to visual characteristics and prominent key molecules. A PubMed research was conducted for the key words; senescence'', quiescence'' and cell cycle arrest''. The results which are related to cell cycle control were selected. The selection criteria of the target articles used for this review included also key cell cycle molecules such as p53, pRB, p21, p16, mTOR, p27, etc. The results were not evaluated statistically. The mechanistic target of rapamycin (mTOR) has been claimed to be key molecule in switching on/off senescence/quiescence. Specifically, although maximal p53 activation blocks mTOR and causes quiescence, partial p53 activation sustains mTOR activity and causes senescence subsequently. In broader perspective, quiescence occurs due to lack of nutrition and growth factors whereas senescence takes place due to aging and serious DNA damages. Contrary to quiescence, senescence is a degenerative process ensuing a certain cell death. We highlighted several differences between senescence and quiescence and their key molecules in this review. Whereas quiescence (cell cycle arrest) is only one half of the senescence, the other half is growth stimulation which causes actual senescence phenotype.en_US
dc.identifier.doi10.1007/s11033-016-4065-0
dc.identifier.endpage1220en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue11en_US
dc.identifier.pmid27558094en_US
dc.identifier.scopus2-s2.0-84983418010en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1213en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-016-4065-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12179
dc.identifier.volume43en_US
dc.identifier.wosWOS:000387671100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSenescenceen_US
dc.subjectQuiescenceen_US
dc.subjectp53en_US
dc.subjectmTORen_US
dc.titleThe cell fate: senescence or quiescenceen_US
dc.typeReview Articleen_US

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