Usefulness of the Neutrophil-to-Lymphocyte Ratio to Predict Bare-Metal Stent Restenosis

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dc.authoridSokmen, Erdogan/0000-0002-8170-5912
dc.authoridOzcan, Firat/0000-0002-7954-7839
dc.contributor.authorTurak, Osman
dc.contributor.authorOzcan, Firat
dc.contributor.authorIsleyen, Ahmet
dc.contributor.authorTok, Derya
dc.contributor.authorSokmen, Erdogan
dc.contributor.authorBuyukkaya, Eyup
dc.contributor.authorAydogdu, Sinan
dc.date.accessioned2024-09-18T21:03:01Z
dc.date.available2024-09-18T21:03:01Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractInflammation plays a crucial role in the pathogenesis of in-stent restenosis (ISR). Neutrophil-to-lymphocyte ratio (NLR) provides a simple method for assessment of inflammatory status and prognosis in patients with coronary artery disease. The aim of the present study was to investigate the predictive value of preprocedural NLR on development of ISR in patients undergoing coronary stent implantation. We retrospectively analyzed clinical, hematologic, and angiographic data of 624 patients (mean age 60.5 +/- 10.2 years, 71.8% men) who had undergone coronary stent implantation and a further control coronary angiography owing to stable or unstable angina pectoris. Patients were divided into 3 tertiles based on preprocedural NLR. Restenosis occurred in 21 patients (10.1%) in the lowest tertile, in 62 (29.8%) in the middle tertile, and in 107 (51.4%) in the highest NLR tertile (p <0.001). Serum C-reactive protein levels were also significantly higher in patients in tertile 3 than in those in tertiles 1 and 2 (p <0.001). Using multiple logistic regression analysis, smoking, diabetes mellitus, stent length, preprocedural NLR, and C-reactive protein levels emerged as independent predictors of ISR. In receiver operating characteristics curve analysis, NLR >2.73 had 80% sensitivity and 75% specificity in predicting ISR. In conclusion, high preprocedural NLR is a powerful and independent predictor of bare-metal stent restenosis in patients with stable and unstable angina pectoris. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved. (Am J Cardiol 2012;110:1405-1410)en_US
dc.identifier.doi10.1016/j.amjcard.2012.07.003
dc.identifier.endpage1410en_US
dc.identifier.issn0002-9149
dc.identifier.issue10en_US
dc.identifier.pmid22858185en_US
dc.identifier.scopus2-s2.0-84868199993en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1405en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjcard.2012.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13206
dc.identifier.volume110en_US
dc.identifier.wosWOS:000311523900003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Inc-Elsevier Science Incen_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPercutaneous Coronary Interventionen_US
dc.subjectLong-Term Mortalityen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectElevated Neutrophilen_US
dc.subjectArtery-Diseaseen_US
dc.subjectUric-Aciden_US
dc.subjectInflammationen_US
dc.subjectRisken_US
dc.subjectCounten_US
dc.titleUsefulness of the Neutrophil-to-Lymphocyte Ratio to Predict Bare-Metal Stent Restenosisen_US
dc.typeArticleen_US

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