Extended autoantibody panel in Turkish patients with early-stage systemic sclerosis: Coexpressions and their influences on clinical phenotypes

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dc.authoridfarisogullari, bayram/0000-0002-9394-1103
dc.authoridKOC, EMRAH/0000-0002-7889-3051
dc.contributor.authorTemiz Karadag, Duygu
dc.contributor.authorKomac, Andac
dc.contributor.authorErez, Yesim
dc.contributor.authorBirlik, Ahmet Merih
dc.contributor.authorSari, Alper
dc.contributor.authorAkdogan, Ali
dc.contributor.authorFarisogullari, Bayram
dc.date.accessioned2024-09-18T20:02:46Z
dc.date.available2024-09-18T20:02:46Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground/AimTo investigate the frequency and clinical relevance of an extended autoantibody profile in patients with systemic sclerosis (SSc).Materials and MethodsIn this cross-sectional study, serum from 100 consecutive patients was subjected to indirect immunofluorescence (IIF) (HEp-20-10/primate liver mosaic) and Systemic Sclerosis Profile by EUROIMMUN to evaluate anti-nuclear antibodies (ANA) and autoantibodies against 13 different autoantibodies in patients with SSc less than 3 years.ResultsNinety-three of 100 patients were positive for ANA by IIF. Fifty-three patients showed single positivity, 26 anti-topoisomerase antibodies (anti-Scl70 ab), 16 anticentromere antibodies (ACAs), six anti-RNA polymerase III antibodies (anti-RNAPIII ab), one anti-Ku antibody, one anti-PM/Scl100 antibody, two anti-PM/Scl75 antibodies, one anti-Ro52 antibody, whereas 32 patients had multiple autoantibody positivities. Among classic SSc-specific autoantibodies, anti-Scl70 and anti-RNAPIII abs showed the highest cooccurrence (n = 4). One patient was simultaneously positive for anti-RNAPIII ab and ACA, and one was positive for ACA and anti-Scl70 ab. The clinical features were not statistically different between single and multiple autoantibody-positivity for classic SSc-specific autoantibodies (ACA, anti-Scl70 ab, and anti-RNAPIII ab), except for digital ulcer in the multiantibody positive ACA group (p = .019).ConclusionBased on our results, coexpression of autoantibodies is not uncommon in SSc patients. Although autoantibodies specific to SSc in early disease show generally known clinical features, it remains to be investigated how the coexpression of autoantibodies will affect clinical presentation. The coexpression of autoantibodies is not uncommon in systemic sclerosis (SSc) patients. Although SSc-specific autoantibodies generally show known clinical features, the clinical presentation of the coexpression in specific and nonspecific autoantibody positivity continues to be necessary.imageen_US
dc.description.sponsorshipActelion companyen_US
dc.description.sponsorshipActelion company contributed financially to the study to be used while purchasing the study kits.en_US
dc.identifier.doi10.1002/iid3.1089
dc.identifier.issn2050-4527
dc.identifier.issue12en_US
dc.identifier.pmid38134320en_US
dc.identifier.scopus2-s2.0-85179307559en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/iid3.1089
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8017
dc.identifier.volume11en_US
dc.identifier.wosWOS:001123335200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofImmunity Inflammation and Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectautoantibodyen_US
dc.subjectimmunoblot assayen_US
dc.subjectindirect immunofluorescence assayen_US
dc.subjectscleroderma-specific antibodiesen_US
dc.subjectsystemic sclerosisen_US
dc.titleExtended autoantibody panel in Turkish patients with early-stage systemic sclerosis: Coexpressions and their influences on clinical phenotypesen_US
dc.typeArticleen_US

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