ASSOCIATION OF FETUIN-A WITH GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND OXIDATIVE STRESS IN SICKLE CELL ANEMIA

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dc.contributor.authorUlutas, Kemal Turker
dc.contributor.authorBuyukbas, Sadik
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorArpaci, Abdullah
dc.contributor.authorKaya, Hasan
dc.date.accessioned2024-09-18T20:57:00Z
dc.date.available2024-09-18T20:57:00Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Oxidative stress has crucial effects over vascular pathophysiology of Sickle Cell Anemia (SCA), and contributes atherosclerosis at advanced stages of the disease. In contrast to be acknowledged the possible role of Fetuin-A in the development of atherosclerosis, its association with vascular changes in SCA appears to warrant further investigation. In the study, we aimed to illuminate vascular pathophysiology of SCA via investigating Fetuin-A levels and its relationship with oxidative stress parameters. Material and methods: Fourty SCA patients and and 35 healthy individuals (n: 35) were included in the study all. After analyzing hematological data, Malondialdehyde (MDA), Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD) and Catalase (CAT) were measured throughout preparing hemolysate from samples with EDTA. Fetuin-A was analyzed from serum samples. Results: Fetuin-A (p<0.001) and MDA levels (p<0.001) were measured significantly higher in SCA group. Similarly, G6PD (p<0.001) and SOD (p<0.01) enzyme activities were determined higher in SCA when compared to the control group. A novel positive correlation was found among Fetuin-A, G6PD (r=0.435, p<0.0001) and MDA (r=0.547, p<0.0001). However, there was no statistical significance between the groups for CAT and GSH-Px. ROC analyze suggested 0,97 ng/mL as the cutoff value for Fetuin-A (Area Under the Curve: 0.713, sensitivity: 62%, specificity: 80%, p:0,002) and 0,06 mu mol/gr Hb as the cutoff value for MDA (Area Under the Curve: 0.898, sensitivity: 87 %, specificity: 80%, p:<0,001). Conclusion: Elevated Fetuin-A in patients with SCA and its positive correlations with both MDA and G6PD suggested that Fetuin-A might have an important role for pathophysiology of SCA. Additionally, Fetuin-A may be useful for evaluating severity of disease with high specificity cutoff value as MDA.en_US
dc.description.sponsorshipBAP Foundation of Mustafa Kemal University, Turkeyen_US
dc.description.sponsorshipThis research was supported by BAP Foundation of Mustafa Kemal University, Turkey. We thank our colleagues who provided insight and expertise that greatly assisted the research, although they may not agree with all of the conclusions of this paper. additionally, we thank Ahmet Bulent TURHAN, Zafer YONDEN, Oktay Hasan OZTURK, Ahmet Burak GURPINAR and Cetin KILINC for comments and positive shares that greatly improved the manuscripten_US
dc.identifier.doi10.19193/0393-6384_2016_3_116
dc.identifier.endpage965en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84994316395en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage959en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2016_3_116
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12233
dc.identifier.volume32en_US
dc.identifier.wosWOS:000384887000016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle Cell Anemiaen_US
dc.subjectFetuin-Aen_US
dc.subjectG6PDen_US
dc.subjectoxidative stressen_US
dc.titleASSOCIATION OF FETUIN-A WITH GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND OXIDATIVE STRESS IN SICKLE CELL ANEMIAen_US
dc.typeArticleen_US

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