Frequency, Distribution and Genotyping of Malassezia Species in Patients with Psoriasis vulgaris

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dc.contributor.authorCelik, Ebru
dc.contributor.authorDuran, Nizami
dc.contributor.authorBalci, Didem Didar
dc.contributor.authorDogramaci, Asena Cigdem
dc.contributor.authorPasa, Ozgur
dc.date.accessioned2024-09-18T20:55:31Z
dc.date.available2024-09-18T20:55:31Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractBackground: Malassezia species are reported to play a role in the etiology of Psoriasis vulgaris. Objective: The aim of this study was to determine the presence, frequency, distribution, and genotyping of skin colonization of Malassezia species in Psoriasis vulgaris and to compare with healthy individuals and to investigate its relationship with the severity of the disease. Methods: Skin samples were taken from scalp, arm, body, and leg of 34 psoriasis patients (lesional/ non-lesional skin) and 30 healthy volunteers. Overall, 392 skin scraping samples were taken for the isolation of Malassezia species, which were incubated on the modified-Dixon agar. Conventional culture methods were used for Malassezia species identification. In isolates, genotyping was carried out by PCR-RFLP method. Results: In the samples from psoriatic lesions, most frequently isolated Malassezia species were M.globosa and M.furfur. Similarly, the most frequently isolated species in healthy volunteers was M. globosa; followed by M.restricta and M.sympodialis. The M.furfur isolation rate in psoriatic scalp and leg lesions of the patients was significantly higher than in healthy volunteers. There was no relationship between the severity of the disease and the isolated species. Conclusion: It was found that there was a difference between patients with psoriasis and healthy controls regarding presence and frequency of Malassezia species. Therefore, our study results support the view that Malessezia species may be associated with the etiopathogenesis of psoriasis. In addition, we surmise that the treatment applications for the regulation of skin microbiota of psoriasis patients will contribute positively to the treatment of psoriasis.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Fund, Hatay, Turkey [04M0103/2009]en_US
dc.description.sponsorshipThe study was supported by Hatay Mustafa Kemal University Scientific Research Fund as project number 04M0103/2009, Hatay, Turkey.en_US
dc.identifier.doi10.2478/rrlm-2021-0011
dc.identifier.endpage227en_US
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue2en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.2478/rrlm-2021-0011
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11895
dc.identifier.volume29en_US
dc.identifier.wosWOS:000657769600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv Pressen_US
dc.relation.ispartofRevista Romana De Medicina De Laboratoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpsoriasis vulgarisen_US
dc.subjectmalasseziaen_US
dc.subjectPCR-RFLPen_US
dc.subjectgenotypingen_US
dc.subjectmodified-Dixon agaren_US
dc.subjectmicrobiotaen_US
dc.titleFrequency, Distribution and Genotyping of Malassezia Species in Patients with Psoriasis vulgarisen_US
dc.typeArticleen_US

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