Tumor budding and E-Cadherin expression in endometrial carcinoma: Are they prognostic factors in endometrial cancer?

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dc.authoridKoyuncuoglu, Meral/0000-0003-1347-8110
dc.contributor.authorKoyuncuoglu, Meral
dc.contributor.authorOkyay, Emre
dc.contributor.authorSaatli, Bahadir
dc.contributor.authorOlgan, Safak
dc.contributor.authorAkin, Mustafa
dc.contributor.authorSaygili, Ugur
dc.date.accessioned2024-09-18T20:16:52Z
dc.date.available2024-09-18T20:16:52Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective. To evaluate the prognostic value of tumor budding (TB) in endometrioid (EEC) and non-endometrioid endometrial cancers (NEEC) and to determine its correlation with expression of E-cadherin. Methods. Ninety-five patients with primary endometrial carcinoma were examined statistically. All patients were diagnosed, treated, and given follow-up care at Dokuz Eylul University Faculty of Medicine. Tumor budding detected by either H&E-stained sections and anticytokeratin-staining C11. The tissue block with the largest invasive front was chosen for budding counting and immunostaining. E-cadherin expression was examined by immunohistochemistry using the primary antibodies against to it. Results. Tumor budding was low-grade in 73 and high-grade in 22 cases. E-cadherin expression loss was identified in 48 patients. The high-grade TB was significantly higher in patients with advanced stage and deep myometrial invasion (p = 0.032 and 0.018, respectively). E-Cadherin expression was significantly lower in NEECs than EECs (p=0.032). The negative expression of E-cadherin was associated with advanced stage and poor differentiation (p = 0.001 and p = 0.024, respectively). We determined that tumor budding adversely correlated with the presence of E-cadherin expression but not statistically significant. Based on the results of multivariate analysis, TB has an independent impact on cumulative overall survival. We found no statistically significant difference between E-cadherin expression and survival. Conclusions. TB is associated with undifferentiated tumor, advanced stage and decreased postoperative survival in endometrial cancer. It might be a valuable prognostic clinicopathologic factor which can be applicable in routine examination. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ygyno.2011.12.433
dc.identifier.endpage213en_US
dc.identifier.issn0090-8258
dc.identifier.issue1en_US
dc.identifier.pmid22198340en_US
dc.identifier.scopus2-s2.0-84858338803en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.1016/j.ygyno.2011.12.433
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9784
dc.identifier.volume125en_US
dc.identifier.wosWOS:000301879600037en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofGynecologic Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrial carcinomaen_US
dc.subjectBuddingen_US
dc.subjectE-cadherinen_US
dc.subjectPrognosisen_US
dc.titleTumor budding and E-Cadherin expression in endometrial carcinoma: Are they prognostic factors in endometrial cancer?en_US
dc.typeArticleen_US

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