The Effect of Alpha Lipoic Acid on Cerebrospinal Fluid Biochemistry and Brain Edema After Experimental Traumatic Brain Injury

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dc.authoridkul, gulnur/0000-0001-7317-3461
dc.authoridtekiner, ayhan/0000-0002-3835-2568
dc.contributor.authorKul, Halil
dc.contributor.authorCelik, Haydar
dc.contributor.authorKurtulu, Adem
dc.contributor.authorTekiner, Ayhan
dc.contributor.authorErdem, Yavuz
dc.contributor.authorKul, Gulnur
dc.contributor.authorBayar, Mehmet Akif
dc.date.accessioned2024-09-18T19:52:38Z
dc.date.available2024-09-18T19:52:38Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: To investigate the effect of alpha lipoic acid on cerebrospinal fluid (CSF) osmolarity and brain tissue water ratio in a rabbit model of traumatic brain injury. MATERIAL and METHODS: Using a previously established model of traumatic brain injury using liquid nitrogen, 36 New Zealand rabbits were randomized into six groups (three treatment groups, a no trauma/no treatment group, a trauma/no treatment group, and a no trauma/treatment group). The treatment groups were administered intravenous alpha lipoic acid at different times of the experiment. Cerebrospinal fluid was obtained 96 hours after injury/treatment via cisterna magna puncture; glucose, blood urea nitrogen, and sodium levels were measured and osmolarity was calculated. Brain tissue water ratio was determined using wet and dry brain weights. The therapeutic effect of alpha lipoic acid was evaluated by comparing cerebrospinal fluid osmolarity and brain tissue water ratio between study groups. RESULTS: Based on cerebrospinal fluid osmolarity values, alpha lipoic acid treatment effectiveness was greatest in the group that received 3 doses after trauma. CONCLUSION: Alpha lipoic acid is effictive in the treatment of brain edema after experimental traumatic brain injury.en_US
dc.identifier.doi10.5137/1019-5149.JTN.27589-19.3
dc.identifier.endpage672en_US
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.pmid32239485en_US
dc.identifier.startpage666en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.27589-19.3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7571
dc.identifier.volume30en_US
dc.identifier.wosWOS:000574422300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectBrain edemaen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectRabbitsen_US
dc.titleThe Effect of Alpha Lipoic Acid on Cerebrospinal Fluid Biochemistry and Brain Edema After Experimental Traumatic Brain Injuryen_US
dc.typeArticleen_US

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