Visceral to subcutaneous fat ratio predicts short- term mortality in patients with Covid 19. A multicenter study

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dc.authoridCHOUSEIN, OUGKOUR/0000-0001-5853-680X
dc.authoridKardas, Hakan/0000-0002-2963-2138
dc.contributor.authorSurov, Alexey
dc.contributor.authorThormann, Maximilian
dc.contributor.authorKardas, Hakan
dc.contributor.authorHinnerichs, Mattes
dc.contributor.authorOmari, Jazan
dc.contributor.authorCingoz, Eda
dc.contributor.authorCingoz, Mehmet
dc.date.accessioned2024-09-18T21:06:33Z
dc.date.available2024-09-18T21:06:33Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To evaluate the association of body composi-tion parameters with outcomes in Covid- 19.Methods:173 patients hospitalized for Covid- 19 infection in 6 European centers were included in this retrospective study. Measurements were performed at L3 -level and comprised skeletal muscle index (SMI), muscle density (MD), and adipose tissue measurements [visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intramuscular adipose tissue (IMAT), visceral -to-subcutaneous-adipose-tissue-area-ratio (VSR)]. The association with mortality, the need for intubation (MV), and the need for admission to ICU within 30 days were evaluated.Results: Higher SAT density was associated with a greater risk of MV (OR = 1.071, 95%CI=(1.034;1.110), p < 0.001). Higher VAT density was associated with admission to ICU (OR = 1.068, 95%CI=(1.029;1.109), p < 0.001). Higher MD was a protective factor for MV and ICU admission (OR = 0.914, 95%CI=(0.870;0.960), p < 0.001; OR = 0.882, 95%CI=(0.832;0.934), p = 0.028). Higher VSR was associated with mortality (OR = 2.147, 95%CI=(1.022;4.512), p = 0.044). Male sex showed the strongest influence on the risk of ICU admission and MV. SMI was not associated with either parameter.Conclusion: In patients hospitalized for Covid- 19 infec-tion, higher VSR seems to be a strong prognostic factor of short -term mortality. Weak associations with clinical course were found for MD and adipose tissue measure-ments. Male sex was the strongest prognostic factor of adverse clinical course.Advances in knowledge: VSR is a prognostic biomarker for 30 -day mortality in patients hospitalized for Covid- 19 disease.en_US
dc.description.sponsorshipProjekt DEAL; German Federal Ministry of Education and Research (BMBF) as part of the University Medicine Network [01KX2021]en_US
dc.description.sponsorshipThis research was supported by the German Federal Ministry of Education and Research (BMBF) as part of the University Medicine Network (Project RACOON, 01KX2021). Open Access funding enabled and organized by Projekt DEAL.en_US
dc.identifier.doi10.1259/bjr.20220869
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1144en_US
dc.identifier.pmid36744766en_US
dc.identifier.scopus2-s2.0-85150751153en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1259/bjr.20220869
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13682
dc.identifier.volume96en_US
dc.identifier.wosWOS:000983400100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBritish Inst Radiologyen_US
dc.relation.ispartofBritish Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleVisceral to subcutaneous fat ratio predicts short- term mortality in patients with Covid 19. A multicenter studyen_US
dc.typeArticleen_US

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