Do antidiabetic drugs prevent the transformation of Acanthamoeba trophozoite into cyst form?

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dc.contributor.authorOzpinar, Necati
dc.contributor.authorKaraman, Ulku
dc.contributor.authorOzpinar, Hulya
dc.contributor.authorDag, Seker
dc.date.accessioned2024-09-18T19:48:01Z
dc.date.available2024-09-18T19:48:01Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study examines the effects of three different drugs with metformin, acarbose and pioglitazone active ingredients used for antidiabetic purposes on Acanthamoeba cysts and trophozoites. Cultures of A. castellanii trophozoites and cysts were prepared to test the anti-amoebic activity of metformin, acarbose and pioglitazone. Cultures were then prepared for A. castellanii cyst and trophozoite forms and parasites were exposed to different concentrations (0.750 mg/mL, 0.375 mg/mL, 0.186 mg/mL and 0.093 mg/mL) of metformin, acarbose and pioglitazone. As a result of the study, the reproductive potential suppressive effects and conversion from trophozoite form to cyst form of all three substances on A. castellanii trophozoites and cysts were determined. Parasites were counted at 12, 24 and 48 hours in the cell counter after staining with trypan blue. In comparison of the effects of metformin, acarbose and pioglitazone used in the study on A. castellanii trophozoites and cysts, it was observed that all three substances were statistically effective against cysts and trophozoites at a concentration of 0.750 mg/mL. Furthermore, it was determined that all concentrations of the three active substances included in the study significantly decreased the rate of cyst formation even at the end of the 7th day. In this context, it was determined that all three substances have amebicidal effects, and they significantly inhibit the transformation of A. castellanii trophozoites to cyst form. It is thought that these active substances, which are currently used as anti-diabetic, can be used in combination with other drugs in A. castellanii infections based on our study findings.en_US
dc.identifier.doi10.1080/20477724.2022.2151859
dc.identifier.endpage680en_US
dc.identifier.issn2047-7724
dc.identifier.issn2047-7732
dc.identifier.issue7en_US
dc.identifier.pmid36436006en_US
dc.identifier.scopus2-s2.0-85142790590en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage674en_US
dc.identifier.urihttps://doi.org/10.1080/20477724.2022.2151859
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7296
dc.identifier.volume117en_US
dc.identifier.wosWOS:000890388100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPathogens and Global Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcanthamoebaen_US
dc.subjectamoebicidal activityen_US
dc.subjectantidiabetic drugsen_US
dc.subjectmetforminen_US
dc.subjectacarboseen_US
dc.subjectpioglitazoneen_US
dc.titleDo antidiabetic drugs prevent the transformation of Acanthamoeba trophozoite into cyst form?en_US
dc.typeArticleen_US

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