The relationship between paraoxonase-1 activity and coronary artery disease in patients with metabolic syndrome

Basit Öğe Kaydı
dc.contributor.authorAkcay, Adnan Burak
dc.contributor.authorCamsari, Ahmet
dc.contributor.authorOzcan, Turkay
dc.contributor.authorCicek, Dilek
dc.contributor.authorAkkus, Necdet
dc.contributor.authorSeyis, Sabri
dc.contributor.authorCimen, Burak
dc.date.accessioned2024-09-18T19:54:21Z
dc.date.available2024-09-18T19:54:21Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: We investigated the correlation of serum paraoxonase-1 (PON-1) activity with coronary artery disease (CAD) in patients with metabolic syndrome (MetS). Study design: The study included 21 patients (mean age 55 +/- 9 years) with MetS, stable angina pectoris, and angiographically shown CAD, 24 patients (mean age 51 +/- 10 years) with MetS and angiographically normal coroner arteries, and 28 healthy controls (mean age 49 +/- 12 years). Demographic and clinical characteristics, insulin levels, homeostasis model assessment of insulin resistance index, and PON- 1 activity were assessed in all the groups. Severity of CAD was assessed using the Gensini score. Results: Paraoxonase-1 activity was significantly lower in patients with MetS compared to the control group (p= 0.02). The two MetS groups with and without CAD exhibited similar characteristics in all the parameters including PON-1 activity (p>0.05). Univariate correlation analysis performed in MetS-CAD patients showed a significant negative correlation between the Gensini score and PON-1 activity (r=-0.48, p=0.02). The overall PON- 1 activity of all the subjects showed no correlation with the parameters examined. Conclusion: Decreased PON-1 activity in patients with MetS compared to the control group suggests increased oxidative stress in MetS. Detection of similar PON-1 activity levels in MetS groups with and without CAD suggests that disturbance of oxidative- antioxidative balance occurs before the development of CAD. The negative correlation between the Gensini score and PON-1 activity implies that decreased PON-1 activity may be one of the etiologic causes of atherosclerotic progress in MetS.en_US
dc.identifier.doi10.5543/tkda.2011.01382
dc.identifier.endpage377en_US
dc.identifier.issn1016-5169
dc.identifier.issue5en_US
dc.identifier.pmid21743260en_US
dc.identifier.scopus2-s2.0-84555188314en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage371en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2011.01382
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7681
dc.identifier.volume39en_US
dc.identifier.wosWOS:000421531500003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngina pectorisen_US
dc.subjectaryldialkylphosphatase/blooden_US
dc.subjectcoronary artery diseaseen_US
dc.subjectmetabolic syndrome Xen_US
dc.titleThe relationship between paraoxonase-1 activity and coronary artery disease in patients with metabolic syndromeen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7681.pdf
Boyut:
482.32 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu