GC-MS analysis and antileishmanial activities of two Turkish propolis types

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dc.authoridMUZ, Mustafa Necati/0000-0002-1769-8498
dc.contributor.authorDuran, Nizami
dc.contributor.authorMuz, Mustafa
dc.contributor.authorCulha, Gulnaz
dc.contributor.authorDuran, Gulay
dc.contributor.authorOzer, Burcin
dc.date.accessioned2024-09-18T21:02:55Z
dc.date.available2024-09-18T21:02:55Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPropolis is a honeybee product with a very complex chemical composition and various pharmacological properties. This study was aimed to investigate antileishmanial activities of Bursa and Hatay propolis samples against Leishmania infantum and Leishmania tropica strains. Propolis samples were analysed with the gas chromatography-mass spectrometry technique. Promastigotes were incubated in Roswell Park Memorial Institute culture medium in the absence and presence of several concentrations (50, 100, 250, 500, 750, and 1,000 mu g/mL) of each propolis sample. The viability and cell morphology of promastigotes in each concentration were examined after 24, 48, 72, and 96 h of incubation. The growth of leishmania parasites was significantly suppressed in the presence of 500, 750, and 1,000 mu g/mL of Hatay propolis. Bursa propolis was found to be efficient in inhibiting the growth of leishmania promastigotes in culture media at these concentrations, 250, 500, 750, and 1,000 mu g/mL. Thus, the in vitro results showed that the Hatay and Bursa propolis samples decreased significantly the proliferation of L. infantum and L. tropica parasites (p<0.001); however, Bursa propolis was found to be more effective than Hatay propolis against leishmania promastigotes. These two natural products may be useful agents in the prevention of leishmanial infections.en_US
dc.identifier.doi10.1007/s00436-010-2039-z
dc.identifier.endpage105en_US
dc.identifier.issn0932-0113
dc.identifier.issue1en_US
dc.identifier.pmid20842509en_US
dc.identifier.scopus2-s2.0-78751580470en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.1007/s00436-010-2039-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13135
dc.identifier.volume108en_US
dc.identifier.wosWOS:000286494800010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofParasitology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIn-Vitroen_US
dc.subjectBrazilian Propolisen_US
dc.subjectChemical-Compositionen_US
dc.subjectBulgarian Propolisen_US
dc.subjectLeishmaniasisen_US
dc.subjectKeratitisen_US
dc.subjectRabbitsen_US
dc.subjectConstituentsen_US
dc.subjectSamplesen_US
dc.subjectGreenen_US
dc.titleGC-MS analysis and antileishmanial activities of two Turkish propolis typesen_US
dc.typeArticleen_US

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