AMELIORATIVE EFFECT OF ASTAXANTHIN ON ISCHEMIA-REPERFUSION INJURY OF SKELETAL MUSCLES

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dc.authoridbengu, aydin sukru/0000-0002-7635-4855
dc.contributor.authorUyar, A.
dc.contributor.authorAkkoyun, H. T.
dc.contributor.authorBengu, A. S.
dc.contributor.authorAkkoyun, M. B.
dc.contributor.authorKeles, O. f.
dc.contributor.authorAtcali, T.
dc.contributor.authorMelek, S.
dc.date.accessioned2024-09-18T20:28:04Z
dc.date.available2024-09-18T20:28:04Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis experimental study aimed to investigate the ameliorative effect of astaxanthin (AST) on the prevention of skeletal muscle injury resulting from lower extremity ischemia/reperfusion (I/R). Twenty-eight (250-300g) male Wistar albino rats were divided into 4 groups as Control, I/R, I/R+AST and AST. In the control group, only anesthesia was induced for 2 h without I/R. In the I/R group, 2 h of reperfusion was facilitated following ischemia under anesthesia. For the I/R+AST group, 7 days prior to ischemia, 125 mg/kg AST was given through a gavage, and 2 h of ischemia and 2 h of reperfusion were facilitated under anesthesia. At the end of the study, blood and gastrocnemius muscle tissue samples were taken for biochemical, histopathological and immunohistochemical examinations. Compared to the control group, there were increased Malondialdehyde (MDA) levels and decreased Superoxide dismutase (SOD) and Catalase (CAT) enzyme activities in the I/R group (p??0.001). Degeneration, necrosis, inflammation, loss of striation, interfibrillar and interfascicular edema were seen in the histopathological examination of the skeletal muscles in the I/R group. These histopathological findings were minimal in the I/R+AST group. In the immunohistochemical examination of muscle tissue with the GPx1 primary antibody, a mild degree of GPx1 reactivity was observed in the I/R group, and a moderate degree of GPx1 reactivity was seen in the I/R+AST group. As a result, the strong ameliorative effect of AST on ischemia-reperfusion injury and its complications on skeletal muscles was demonstrated by biochemical, histopathological and immunohistochemical examinations.en_US
dc.identifier.doi10.36899/JAPS.2022.4.0494
dc.identifier.endpage933en_US
dc.identifier.issn1018-7081
dc.identifier.issn2309-8694
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85138742944en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage924en_US
dc.identifier.urihttps://doi.org/10.36899/JAPS.2022.4.0494
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10715
dc.identifier.volume32en_US
dc.identifier.wosWOS:000835073500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPakistan Agricultural Scientists Forumen_US
dc.relation.ispartofJournal of Animal and Plant Sciences-Japsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectMuscleen_US
dc.subjectAstaxanthinen_US
dc.subjectMDAen_US
dc.subjectSODen_US
dc.subjectCATen_US
dc.subjectHistopathologyen_US
dc.titleAMELIORATIVE EFFECT OF ASTAXANTHIN ON ISCHEMIA-REPERFUSION INJURY OF SKELETAL MUSCLESen_US
dc.typeArticleen_US

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