The Effects of Low-Dose Erythropoiesis-Stimulating Agents on Peritoneal Fibrosis Induced by Chemical Peritonitis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Rats

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dc.authoridOzkan, Orhan Veli/0000-0002-2862-294X
dc.contributor.authorYildirim, Ayse
dc.contributor.authorOzkan, Orhan Veli
dc.contributor.authorAslan, Ahmet
dc.contributor.authorKoseoglu, Zikret
dc.contributor.authorBorazan, Ali
dc.date.accessioned2024-09-18T20:54:11Z
dc.date.available2024-09-18T20:54:11Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim. The objective of the present study was to investigate the effect of low-dose erytropoesis-stimulating agents (ESA) on the development of peritoneal fibrosis in chlorhexidine gluconate-induced peritoneal sclerosing rats and to assess the peritoneal tissue levels of MMP-2 and TIMP-2, which may be regarded as factors in the development of peritoneal fibrosis. Subjects and methods. Twenty-four Wistar albino rats were divided into three groups. The control group received 0.9% saline (3 ml/d) intraperitoneally, the CH group received 3 ml daily injections of 0.1% chlorhexidine gluconate (CH) intraperitoneally, and the CH+ESA group received 3 ml daily injections of 0.1% CH intraperitoneally and epoetin beta (3 x 20 IU/kg/week) subcutaneously. On the twenth-first day, rats were sacrificed, and parietal peritoneum samples were obtained from the left anterior abdominal wall. Pathological samples were examined using Hematoxyline & Eosin (HE) stains. The thickness, vascular proliferation, and inflammation were determined by light microscopy. MMP-2 and TIMP-2 were studied immunohistochemically by monoclonal antibody staining. Results. Inflammation, vascular proliferation, and fibrotic area percentages were not statistically significant between groups. Histopathologically control, CH, CH+ESA groups peritoneal thickness were 8.02 +/- 2.89, 146.74 +/- 26.1, and 48.12 +/- 16.8 micrometers, respectively. The decrease in thickness of parietal peritoneum in CH+ESA group was statistically significant when compared to CH. Immunohistochemically, interferon was shown to decrease MMP-2 expression on parietal peritoneum than group CH, but has no effect on TIMP-2. Discussion. Low-dose ESA histopatologically reduces peritoneal fibrosis induced by chlorhexidine gluconate. However, from dosage and duration points of view, we need extended clinical and experimental studies.en_US
dc.identifier.doi10.1080/08860220903033716
dc.identifier.endpage572en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid19839852en_US
dc.identifier.scopus2-s2.0-72649090828en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage567en_US
dc.identifier.urihttps://doi.org/10.1080/08860220903033716
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11650
dc.identifier.volume31en_US
dc.identifier.wosWOS:000271014900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectperitoneal fibrosisen_US
dc.subjecterythropoiesis stimulating agentsen_US
dc.subjectMMP-2en_US
dc.subjectTIMP-2en_US
dc.titleThe Effects of Low-Dose Erythropoiesis-Stimulating Agents on Peritoneal Fibrosis Induced by Chemical Peritonitis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Ratsen_US
dc.typeArticleen_US

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