Glutathione and nitrite levels in induced sputum at COPD patients and healthy smokers

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dc.authoridAKPOLAT, NUSRET/0000-0002-9138-2117
dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.contributor.authorTurgut, Teyfik
dc.contributor.authorIlhan, Nevin
dc.contributor.authorDeveci, Figen
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorErden, Ersin Sukru
dc.contributor.authorMuz, M. Hamdi
dc.date.accessioned2024-09-18T20:25:25Z
dc.date.available2024-09-18T20:25:25Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractObjectives: The role of oxidative stress at the pathogenesis of chronic obstructive pulmonary disease (COPD) is known. The aim of this study is to investigate the oxidative stress with sputum induction that is a simple method in COPD patients and healthy smokers. Methods: Sputum induction was performed in 21 COPD patients (10 stable, 11 acute exacerbations), nine healthy smokers, and ten healthy non-smokers. Glutathione, NO2- levels, and cell counts at sputum, and plasma NO2- contents were evaluated in all subjects. Results: Mean sputum glutathione and NO2- levels were significantly higher in acute exacerbations with COPD patients than healthy smokers (P=0.007 and P<0.001 respectively), and non-smokers (P<0.001 and P<0.001 respectively). On the other hand, sputum glutathione and NO2- levels did not show significant differences between stable and acute exacerbations with COPD patients. Although, sputum glutathione levels were higher in stable COPD patients than healthy smokers', no statistically significant difference was established. In addition, sputum glutathione levels were significantly higher in healthy smokers than nonsmokers (P<0.001). Conclusions: As a result, we can say that oxidative stress increases not only in COPD patients but also in healthy smokers. In addition, sputum induction that is a simple method can be used to demonstrate to show oxidative stress.en_US
dc.identifier.doi10.3978/j.issn.2072-1439.2014.04.24
dc.identifier.endpage771en_US
dc.identifier.issn2072-1439
dc.identifier.issn2077-6624
dc.identifier.issue6en_US
dc.identifier.pmid24977001en_US
dc.identifier.scopus2-s2.0-84904887416en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage765en_US
dc.identifier.urihttps://doi.org/10.3978/j.issn.2072-1439.2014.04.24
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10292
dc.identifier.volume6en_US
dc.identifier.wosWOS:000339348300052en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPioneer Bioscience Publ Coen_US
dc.relation.ispartofJournal of Thoracic Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathioneen_US
dc.subjectnitriteen_US
dc.subjectinduced sputumen_US
dc.subjectchronic obstructive pulmonary disease (COPD)en_US
dc.titleGlutathione and nitrite levels in induced sputum at COPD patients and healthy smokersen_US
dc.typeArticleen_US

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