Diagnostic accuracy of angiopoietin-like protein 2 and atherosclerotic variables in psoriasis vulgaris using ROC analysis

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dc.contributor.authorCelik, Ebru
dc.contributor.authorCelik, Yusuf
dc.contributor.authorBurakgazi, Gulen
dc.contributor.authorCakirca, Gokhan
dc.contributor.authorUcgul, Gokhan
dc.date.accessioned2024-09-18T19:54:22Z
dc.date.available2024-09-18T19:54:22Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractAim: Psoriasis vulgaris is a chronic inflammatory skin disease associated with various comorbidities such as metabolic syndrome and cardiovascular disease. The disease is affected by many variables. Angiopoietin-like protein 2 (ANGPTL2) is a proinflammatory cytokine, and increased serum levels are associated with inflammation, obesity, dyslipidemia, metabolic syndrome, and atherosclerosis. The aim of this study was to determine the diagnostic accuracy of the new variable ANGPTL2 and other atherosclerotic variables for psoriasis, using Receiver Operating Characteristic (ROC) analysis. Material and Methods: The study included 41 psoriasis patients and 43 healthy volunteers. Ultrasound examination of the carotids and carotid intima-media thickness (CIMT) measurements were performed in all participants. Serum ANGPTL2 levels, lipid levels/ratios and anthropometric measurements were recorded. A ROC curve of multivariate statistical methods was used for statistical evaluation. Results: According to the results of the ROC curves, seven diagnostic variables (ANGPTL2, BMI, weight, systolic blood pressure, waist circumference for females, uric acid and LDL-cholesterol) were found to be significant. The highest Area Under the Curve (AUC) value was found for ANGPTL2; AUC=0.721, 95% CI: 0.595-0.847, p=0.002. There was no significant difference in the lipid ratios and CIMT measurements between psoriasis patients and healthy controls. Discussion: This study revealed that increased ANGPTL2 levels in psoriasis patients are evidence of the strong relationship between the disease and atherosclerosis. Therefore, the measurement of serum ANGPTL2 level may be a new marker that can be used to determine the risk of early atherosclerosis and metabolic complications in psoriasis patients.en_US
dc.identifier.doi10.4328/ACAM.20551
dc.identifier.endpage461en_US
dc.identifier.issn2667-663X
dc.identifier.issue4en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.20551
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7695
dc.identifier.volume12en_US
dc.identifier.wosWOS:000645110200021en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectANGPTL2en_US
dc.subjectPsoriasis vulgarisen_US
dc.subjectAtherosclerosisen_US
dc.subjectROC analysisen_US
dc.titleDiagnostic accuracy of angiopoietin-like protein 2 and atherosclerotic variables in psoriasis vulgaris using ROC analysisen_US
dc.typeArticleen_US

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