Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

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dc.authorid, ahmet/0000-0001-6274-5700
dc.contributor.authorTutanc, M.
dc.contributor.authorArica, V.
dc.contributor.authorYilmaz, N.
dc.contributor.authorNacar, A.
dc.contributor.authorZararsiz, I.
dc.contributor.authorBasarslan, F.
dc.contributor.authorTutanc, O. D.
dc.date.accessioned2024-09-18T20:13:42Z
dc.date.available2024-09-18T20:13:42Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group I rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.en_US
dc.description.sponsorshipMustafa Kemal University scientific Research Project Board [1102M0108]en_US
dc.description.sponsorshipBefore the experiment, ethical approval was obtained from Mustafa Kemal University Animal Ethics Committee. This study was supported by Mustafa Kemal University scientific Research Project Board with project number 1102M0108.en_US
dc.identifier.doi10.1177/0960327111417907
dc.identifier.endpage573en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue6en_US
dc.identifier.pmid21813577en_US
dc.identifier.scopus2-s2.0-84861830578en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.1177/0960327111417907
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9334
dc.identifier.volume31en_US
dc.identifier.wosWOS:000304222400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcyclosporinen_US
dc.subjecterdosteineen_US
dc.subjectnephrotoxicityen_US
dc.subjectprotective effecten_US
dc.titleEffects of erdosteine on cyclosporin-A-induced nephrotoxicityen_US
dc.typeArticleen_US

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