Platelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patients

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dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.contributor.authorYaprak, Mustafa
dc.contributor.authorTuran, Mehmet Nuri
dc.contributor.authorDayanan, Ramazan
dc.contributor.authorAkin, Selcuk
dc.contributor.authorDegirmen, Elif
dc.contributor.authorYildirim, Mustafa
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2024-09-18T20:52:44Z
dc.date.available2024-09-18T20:52:44Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were established showing the poor prognosis in some diseases, such as cardiovascular diseases and malignancies. The risk of mortality in patients with end-stage renal disease (ESRD) was higher than normal population. In this study, we aimed to investigate the relationship between NLR, PLR, and all-cause mortality in prevalent hemodialysis (HD) patients. Methods Eighty patients were enrolled in study. NLR and PLR obtained by dividing absolute neutrophil to absolute lymphocyte count and absolute platelet count to absolute lymphocyte count, respectively. The patients were followed prospectively for 24 months. The primary end point was all-cause mortality. Results Mean levels of neutrophil, lymphocyte, and platelet were 3904 +/- 1543/mm(3), 1442 +/- 494/mm(3), 174 +/- 56 x 10(3)/mm(3), respectively. Twenty-one patients died before the follow-up at 24 months. Median NLR and PLR were 2.52 and 130.4, respectively. All-cause mortality was higher in patients with high NLR group compared to the patients with low NLR group (18.8 vs. 7.5 %, p = 0.031) and in patients with higher PLR group compared to patients with lower PLR group (18.8 vs. 7.5 %, p = 0.022). Following adjusted Cox regression analysis, the association of mortality and high NLR was lost (p = 0.54), but the significance of the association of high PLR and mortality increased (p = 0.013). Conclusion Although both NLR and PLR were associated with all-cause mortality in prevalent HD patients, only PLR could independently predict all-cause mortality in these populations.en_US
dc.identifier.doi10.1007/s11255-016-1301-4
dc.identifier.endpage1348en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue8en_US
dc.identifier.pmid27118565en_US
dc.identifier.scopus2-s2.0-84964529895en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1343en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-016-1301-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11348
dc.identifier.volume48en_US
dc.identifier.wosWOS:000381974400020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectPlatelet-to-lymphocyte ratioen_US
dc.subjectInflammationen_US
dc.subjectMortalityen_US
dc.subjectHemodialysisen_US
dc.titlePlatelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patientsen_US
dc.typeArticleen_US

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