Effect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Rats

Basit Öğe Kaydı
dc.authoridOGUZ, Prof. Dr. Halis/0000-0002-9236-0630
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorErdogan, Teslime
dc.contributor.authorOguz, Halis
dc.contributor.authorCorum, Orhan
dc.date.accessioned2024-09-18T20:15:07Z
dc.date.available2024-09-18T20:15:07Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground The simultaneous use of NSAIDs and antibiotics is recommended for bacterial diseases in human and veterinary medicine. Moxifloxacin (MFX) and dexketoprofen (DEX) can be used simultaneously in bacterial infections. However, there are no studies on how the simultaneous use of DEX affects the pharmacokinetics of MFX in rats.Objectives The aim of this study was to determine the effect of DEX on plasma and lung pharmacokinetics of MFX in male and female rats.Methods A total of 132 rats were randomly divided into 2 groups: MFX (n=66, 33 males/33 females) and MFX+DEX (n=66, 33 females/33 males). MFX at a dose of 20 mg/kg and DEX at a dose of 25 mg/kg were administered intraperitoneally. Plasma and lung concentrations of MFX were determined using the high-performance liquid chromatography-UV and pharmacokinetic parameters were evaluated by non-compartmental analysis.Results Simultaneous administration of DEX increased the plasma and lung area under the curve from 0 to 8 h (AUC0-8) and peak concentration (Cmax) of MFX in rats, while it significantly decreased the total body clearance (CL/F). When female and male rats were compared, significant differences were detected in AUC0-8, Cmax, CL/F and volume of distribution. The AUC0-8lung/AUC0-8plasma ratios of MFX were calculated as 1.68 and 1.65 in female rats and 5.15 and 4.90 in male rats after single and combined use, respectively.Conclusion MFX was highly transferred to the lung tissue and this passage was remarkably higher in male rats. However, DEX administration increased the plasma concentration of MFX in both male and female rats but did not change its passage to the lung. However, there is a need for a more detailed investigation of the difference in the pharmacokinetics of MFX in male and female rats.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkiye [20212033]en_US
dc.description.sponsorshipThis study was summarized from a PhD thesis and supported by The Coordination of Scientific Research Projects, University of Selcuk, Turkiye (project no. 20212033).en_US
dc.identifier.doi10.2174/0113892002282271231219044508
dc.identifier.endpage70en_US
dc.identifier.issn1389-2002
dc.identifier.issn1875-5453
dc.identifier.issue1en_US
dc.identifier.pmid38258775en_US
dc.identifier.scopus2-s2.0-85195283338en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.2174/0113892002282271231219044508
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9461
dc.identifier.volume25en_US
dc.identifier.wosWOS:001230762700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Drug Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexketoprofenen_US
dc.subjectgenderen_US
dc.subjectlungen_US
dc.subjectmoxifloxacinen_US
dc.subjectpharmacokineticsen_US
dc.subjectraten_US
dc.titleEffect of Dexketoprofen on the Disposition Kinetics of Moxifloxacin in Plasma and Lung in Male and Female Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu