Performance of QuantiFERON-TB Gold In-Tube test and Tuberculin Skin Test for diagnosis of latent tuberculosis infection in BCG vaccinated health care workers

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dc.authoridBabayigit, Cenk/0000-0001-9760-6081
dc.contributor.authorBabayigit, Cenk
dc.contributor.authorOzer, Burcin
dc.contributor.authorInandi, Tacettin
dc.contributor.authorOzer, Cahit
dc.contributor.authorDuran, Nizami
dc.contributor.authorGocmen, Orhan
dc.date.accessioned2024-09-18T20:57:04Z
dc.date.available2024-09-18T20:57:04Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) but it suffers from a number of well-documented performance and logistic problems. Quantiferon-TB Gold In Tube test (QFT-GIT) has been reported to have better sensitivity and specifity than TST. In this study, it was aimed to compare the performance of a commercial IFN-gamma release assay (QFT-GIT) with TST in the diagnosis of HCWs at risk for latent TB infection in BCG vaccinated population. Material/Methods: Hundred healthy volunteer health care workers were enrolled. All were subjected to TST and QFT-GIT. Results were compared among Health Care Workers (HCWs) groups in terms of profession, workplace, working duration. Results: TST is affected by previous BCG vaccinations and number of cases with QFT-GIT positivity is increased in accordance with the TST induration diameter range. QFT-GIT result was negative in 17 of 32 TST positive (>= 15 mm) cases and positive in 4 of 61 cases whose TST diameters are between 6-14 mm, that is attritutable to previous BCG vaccination(s). It was negative in all cases with TST diameters between 0-5 mm. HCWs with positive QFT-GIT results were significantly older than the ones with negative results. Furthermore duration of work was significantly longer in QFT-GIT positive than in negative HCWs. Conclusions: There was a moderate concordance between QFT-GIT and TST, when TST result was defined as positive with a >= 15 mm diameter of induration. We suggest that QFT-GIT can be used as an alternative to TST for detection of LTBI, especially in groups with high risk of LTBI and in population with routine BCG vaccination program.en_US
dc.identifier.endpage529en_US
dc.identifier.issn1643-3750
dc.identifier.pmid24681806en_US
dc.identifier.scopus2-s2.0-84897461240en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12273
dc.identifier.volume20en_US
dc.identifier.wosWOS:000333669000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSkin Testsen_US
dc.subjectQuantiferon-TB Gold In-Tubeen_US
dc.subjectLatent Tuberculosisen_US
dc.subjectTuberculin Testen_US
dc.titlePerformance of QuantiFERON-TB Gold In-Tube test and Tuberculin Skin Test for diagnosis of latent tuberculosis infection in BCG vaccinated health care workersen_US
dc.typeArticleen_US

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