A histopathological, immunohistochemical and biochemical investigation of the antidiabetic effects of the Pistacia terebinthus in diabetic rats

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dc.contributor.authorUyar, A.
dc.contributor.authorAbdulrahman, N. T.
dc.date.accessioned2024-09-18T19:48:01Z
dc.date.available2024-09-18T19:48:01Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe investigated the antidiabetic activity of Pistacia terebinthus (PT) extracts in streptozotocin (STZ) induced diabetic rats. We used 40 Wistar albino male rats divided into five groups: control (C), diabetes (DM), diabetes + acarbose (DM + AC), diabetes + PT (DM + PT) and PT. DM was established by intraperitoneal injection of STZ. Immunohistochemistry revealed that STZ reduced insulin immunoreactivity in the pancreas of the diabetic rats. To the contrary, insulin immunoreactivity in the pancreatic beta cells of PT treated diabetic rats was increased significantly. Decreased levels of blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glucose, total triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) were found in the PT supplemented diabetic group. Also, malondialdehyde (MDA) and antioxidant defense system enzyme levels were normalized in the DM + PT group. PT exhibited a protective effect on liver, kidney and pancreas that had been damaged by STZ induced DM.en_US
dc.identifier.doi10.1080/10520295.2019.1612092
dc.identifier.endpage104en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid32013588en_US
dc.identifier.scopus2-s2.0-85078924918en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1612092
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7300
dc.identifier.volume95en_US
dc.identifier.wosWOS:000512573100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcarboseen_US
dc.subjectantidiabetic effecten_US
dc.subjectdiabetesen_US
dc.subjectPistacia terebinthusen_US
dc.subjectratsen_US
dc.titleA histopathological, immunohistochemical and biochemical investigation of the antidiabetic effects of the Pistacia terebinthus in diabetic ratsen_US
dc.typeArticleen_US

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