High Prevalence of Pulmonary Hypertension in Homozygous Sickle Cell Patients with Leg Ulceration

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dc.authoridBabayigit, Cenk/0000-0001-9760-6081
dc.contributor.authorSerarslan, Gamze
dc.contributor.authorAkgul, Ferit
dc.contributor.authorBabayigit, Cenk
dc.date.accessioned2024-09-18T20:29:32Z
dc.date.available2024-09-18T20:29:32Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPulmonary hypertension is a common complication and is a risk factor for death in adult patients with sickle cell disease. Chronic leg ulceration is a major cause of morbidity in homozygous sickle cell disease. We aimed to determine prevalence of pulmonary hypertension in homozygous sickle cell patients and if there is any relation of pulmonary hypertension with leg ulceration. A total of 88 patients, asymptomatic for pulmonary hypertension, were enrolled in the study. Doppler echocardiography was performed on homozygous sickle cell patients with and without leg ulceration. 12 patients (10 male, 2 female) had active ulcer or healed scar (group I) and 76 patients (40 male, 36 female) had no active leg ulcer or history of (group II). The prevalence of pulmonary hypertension in group I and group II were 91.6% (n = 11) and 31.6% (n = 24), respectively (p = 0.0001). Patients with leg ulceration had increased left atrium and right ventricular diameters at diastole and also had increased left ventricular end-diastolic and end-systolic diameters. We determined an increased prevalence of pulmonary hypertension in patients with leg ulceration. Patients with homozygous sickle cell disease, especially those with leg ulcers should be screened for pulmonary hypertension, since pulmonary hypertension is a frequent and generally asymptomatic complication and a risk factor of mortality.en_US
dc.identifier.doi10.1080/10641960802404078
dc.identifier.endpage48en_US
dc.identifier.issn1064-1963
dc.identifier.issue1en_US
dc.identifier.pmid19172458en_US
dc.identifier.scopus2-s2.0-60549086981en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.1080/10641960802404078
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10918
dc.identifier.volume31en_US
dc.identifier.wosWOS:000262787200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlegulceren_US
dc.subjectpulmonary hypertensionen_US
dc.subjectsickle cell diseaseen_US
dc.titleHigh Prevalence of Pulmonary Hypertension in Homozygous Sickle Cell Patients with Leg Ulcerationen_US
dc.typeArticleen_US

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