Contractile Effects of Eryngium kotschyi Boiss. on Rat Isolated Ileum and Detrussor Muscle

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dc.authoridBAYDAN, Emine/0000-0001-5459-8616
dc.authoridInce, Sinan/0000-0002-1915-9797
dc.authoridYurdakok-Dikmen, Begum/0000-0002-0385-3602
dc.authoridKARTAL, Murat/0000-0003-3538-2769
dc.authoridEkici, Husamettin/0000-0001-6403-737X
dc.contributor.authorBaydan, Emine
dc.contributor.authorKartal, Murat
dc.contributor.authorYurdakok, Begum
dc.contributor.authorErdem, Sinem Aslan
dc.contributor.authorInce, Sinan
dc.contributor.authorEkici, Husamettin
dc.contributor.authorAlp, Harun
dc.date.accessioned2024-09-18T20:19:50Z
dc.date.available2024-09-18T20:19:50Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractThe pharmacological activity of the aerial (EKA) and root (EKR) parts of the endemic plant, Eryngium kotschyi Boiss., on rat isolated ileum and detrusor muscle was investigated. Plant extracts alone and with the presence of agonist (acethylcholine) and antagonist (atropin, verapamile, oxybutinine-detrusor muscle, and papaverine-ileum) drugs, along with Ca2+ applications on calcium-free medium, were applied. Plant extracts induced contraction in ileum and detrusor muscle where the contractions were concentration dependant for EKA and EKR single dose applications in detrusor muscle and concentration-free contractions were observed in cumulative applications for both tissues. Aerial and root parts of Eryngium extracts induced contractions in dose, tissue and protocol dependent manner where the contractions were affected by the tested antagonists, which could be attributed to non-specific pathways including calcium ions and calcium channel stimulations.en_US
dc.identifier.doi10.9775/kvfd.2014.11110
dc.identifier.endpage785en_US
dc.identifier.issn1300-6045
dc.identifier.issue5en_US
dc.identifier.startpage779en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2014.11110
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9894
dc.identifier.volume20en_US
dc.identifier.wosWOS:000344689400021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEryngium kotschyien_US
dc.subjectDetrusor muscleen_US
dc.subjectBladderen_US
dc.subjectIleumen_US
dc.subjectMotilityen_US
dc.subjectRaten_US
dc.titleContractile Effects of Eryngium kotschyi Boiss. on Rat Isolated Ileum and Detrussor Muscleen_US
dc.typeArticleen_US

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