Agomelatine Protection in an LPS-Induced Psychosis-Relevant Behavior Model

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.contributor.authorInanir, Sema
dc.contributor.authorCopoglu, Umit Sertan
dc.contributor.authorKokacya, Hanifi
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorErbas, Oytun
dc.contributor.authorInanir, Ahmet
dc.date.accessioned2024-09-18T20:04:22Z
dc.date.available2024-09-18T20:04:22Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the effect of agomelatine in a psychosis-relevant behavior model. Material/Methods: We used 18 adult male Wistar rats in this study. Twelve rats given LPS for endotoxemia were randomly divided into 2 groups (n=6). Group I was treated with 1 mL/kg 0.9% NaCl i. p. and Group II was treated with 40 mg/kg agomelatine. Six normal rats served as the control group and were not given LPS for endotoxemia. Cylindrical steel cages containing vertical and horizontal metal bars with top cover were used. Rats were put in these cages for the purpose of orientation for 10 min. Apomorphine was given to rats removed from cages, and then they were immediately put back in the cages for the purpose of observing stereotyped conduct. Brain HVA levels and plasma TNF-alpha levels were evaluated in tissue homogenates using ELISA. The proportion of malondialdehyde (MDA) was measured in samples taken from plasma for detection of lipid peroxidation similar to thiobarbituric acid reactive substances. Results: LPS induced-plasma TNF-alpha, brain TNF-alpha, and plasma MDA levels were significantly lower in the LPS+ agomelatine group compared to the LPS+ saline group (p< 0.05). HVA levels and stereotype scores were significantly lower in the LPS+ agomelatine group compared to the LPS+ saline group (p < 0.001). Conclusions: Agomelatine reduced TNF-alpha, HVA, MDA levels, and the stereotype score in relevant models of psychosis. Our results suggest that the anti-inflammatory effect of agomelatine involved oxidant cleansing properties and that its effects on the metabolism of dopamine can play an important role in the model of psychosis.en_US
dc.identifier.doi10.12659/MSM.895505
dc.identifier.endpage3839en_US
dc.identifier.issn1643-3750
dc.identifier.pmid26647355en_US
dc.identifier.scopus2-s2.0-84949895539en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3834en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.895505
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8111
dc.identifier.volume21en_US
dc.identifier.wosWOS:000367354100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehavior, Animalen_US
dc.subjectPsychotic Disordersen_US
dc.subjectStereotyped Behavioren_US
dc.titleAgomelatine Protection in an LPS-Induced Psychosis-Relevant Behavior Modelen_US
dc.typeArticleen_US

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