Inducible nitric oxide synthase and histopathological correlation in chronic viral hepatitis

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dc.contributor.authorAtik, Esin
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorSavas, Lutfu
dc.contributor.authorDoran, Figen
dc.date.accessioned2024-09-18T20:28:08Z
dc.date.available2024-09-18T20:28:08Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Chronic liver disorders represent a serious health problem. Nitric oxide (NO) synthesized by inducible nitric oxide synthase (iNOS) can function as an antimicrobial agent able to kill or reduce replication of microorganisms, and plays an important role in immune regulation. This study was undertaken to evaluate the expression of iNOS in chronic viral hepatitis and its relation to histopathology. Methods: This study included 56 patients with chronic viral hepatitis (38 hepatitis B, 18 hepatitis C). There were 35 men and 21 women with a mean age of 38.6 +/- 21.731 years. A modified form of the histology activity index (HAI) designed by Ishak and colleagues was used to assess grading and staging of chronic viral hepatitis. The needle biopsy specimens were fixed in 10% formalin and routinely processed. Routine hematoxylin-eosin, periodic acid-Schiff, and reticulin staining, and iNOS immunoperoxidase technique were performed on paraffin-embedded tissues. Results: We demonstrated that all Liver samples had a marked iNOS expression, with a diffuse distribution pattern. iNOS consistently labeled mononuclear cells infiltrating portal tracts in all samples. Statistical evaluation of data showed that the iNOS expression correlated with the HAI and fibrosis. Furthermore a correlation between iNOS and severity of disease was detected (r = 0.772, p = 0.000). Conclusions: Further investigations are required to determine whether iNOS-related treatment protocols could be useful in reducing disease severity. (C) 2007 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijid.2007.03.010
dc.identifier.endpage15en_US
dc.identifier.issn1201-9712
dc.identifier.issue1en_US
dc.identifier.pmid17553719en_US
dc.identifier.scopus2-s2.0-37349095272en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2007.03.010
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10752
dc.identifier.volume12en_US
dc.identifier.wosWOS:000252675500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectiNOS (inducible nitric oxide synthase)en_US
dc.subjectviral hepatitisen_US
dc.subjecthistopathologyen_US
dc.titleInducible nitric oxide synthase and histopathological correlation in chronic viral hepatitisen_US
dc.typeArticleen_US

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