Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid

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dc.contributor.authorRifaioglu, Emine Nur
dc.contributor.authorSen, Bilge Bulbul
dc.contributor.authorEkiz, Ozlem
dc.contributor.authorDogramaci, Asena Cigdem
dc.date.accessioned2024-09-18T20:06:17Z
dc.date.available2024-09-18T20:06:17Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the formation of blisters on normal or erythematous skin. In patients with BP, eosinophils are highly represented in the inflammatory infiltrate of the lesional skin and their levels are often increased in peripheral blood. It is known that eosinophils are the major intravascular source of tissue factor (TF), an initiator of the extrinsic coagulation pathway. Patients with BP are also three times more likely to develop pneumonia and pulmonary embolism than the matched controls. We hypothesized that there might be an association between the eosinophil level and mean platelet volume (MPV) in these patients. Patient and method: A total of 19 patients with BP and age-sex match 22 healthy controls were included in this study retrospectively. MPV before treatment, MPV after treatment, platelet, eosinophil count before treatment, eosinophil count after treatment, white blood cell, glucose, C reactive protein and sedimentation rate were evaluated in BP patients and the control group. Results: The MPV value (8.32fl +/- 1.8) and eosinophil count (1.03x10(3)mu L-1 +/- 0.36) in patients with BP was significantly higher than that of control subjects (p=- 0.036) and (0.22x10(3)mu L-1 +/- 0.29) (p= 0.002) (p< 0.05, Mann-Whitney U-test). Conclusion: In this study high levels of MPV and eosinophil levels have been detected. MPV may be a useful indicator of the risk of vascular events. Prospective studies are needed to compare disease activity, thromboembolic events and MPV in BP patients.en_US
dc.identifier.doi10.3109/09537104.2013.784735
dc.identifier.endpage267en_US
dc.identifier.issn0953-7104
dc.identifier.issn1369-1635
dc.identifier.issue4en_US
dc.identifier.pmid23574380en_US
dc.identifier.scopus2-s2.0-84899980494en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://doi.org/10.3109/09537104.2013.784735
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8440
dc.identifier.volume25en_US
dc.identifier.wosWOS:000336950800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBullous pemphigoiden_US
dc.subjectmean platelet volumeen_US
dc.subjecttissue factoren_US
dc.titleMean platelet volume and eosinophilia relationship in patients with bullous pemphigoiden_US
dc.typeArticleen_US

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