Letrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatonin

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridOzkan, Orhan Veli/0000-0002-2862-294X
dc.contributor.authorAydin, Mehmet
dc.contributor.authorOktar, Suleyman
dc.contributor.authorOzkan, Orhan Veli
dc.contributor.authorAlcin, Ergul
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorNacar, Ahmet
dc.date.accessioned2024-09-18T20:29:33Z
dc.date.available2024-09-18T20:29:33Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim. The aim of this study was to determine the effects of letrozole (LTZ), an aromatase inhibitor (AI), and melatonin (MLT) on hepatic function and oxidative stress in female rats. Material and methods. A total of 32 female rats were divided equally into four groups (n = 8). Control group received saline (0.5 ml/day, oral gavage). LTZ was administered to rats by daily oral gavage at 1 mg/kg dose. LTZ + MLT group was given LTZ (1 mg/kg, oral gavage) plus MLT (0.5 mg/kg/day, s.c.). MLT group was given MLT (0.5 mg/kg/day) by s.c. injection. The activities of superoxide dismutase (SOD) and catalase (CAT) and malondialdehyde (MDA) levels were measured in liver tissue. Total antioxidant capacity (TAC), total oxidant status (TOS), ALT, AST, GGT, ALP, LDH, bilirubin, BUN, creatinine, total cholesterol (TC), high-density lipoprotein (HDL) and triglyceride (TG) were assayed in serum samples. Results. The oxidative stress, parameters did not differ between groups. LTZ administration increased hepatic function parameters such as AST, LDH, ALP, bilirubin and MLT improved the disturbances of hepatic function. LTZ caused minimal histological changes in liver tissue and MLT treatment reversed those dejenerations. Discussion. LTZ may cause hepatotoxicity without inducing oxidative stress and MLT restores hepatic activity.en_US
dc.identifier.doi10.3109/09513590.2010.488769
dc.identifier.endpage215en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue4en_US
dc.identifier.pmid20528203en_US
dc.identifier.scopus2-s2.0-79952409335en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2010.488769
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10935
dc.identifier.volume27en_US
dc.identifier.wosWOS:000288979000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLetrozoleen_US
dc.subjectmelatoninen_US
dc.subjecthepatotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectestrogensen_US
dc.titleLetrozole induces hepatotoxicity without causing oxidative stress: the protective effect of melatoninen_US
dc.typeArticleen_US

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