Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata

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dc.contributor.authorMotor, Sedat
dc.contributor.authorOzturk, Sahin
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorGurpinar, Ahmet Burak
dc.contributor.authorCan, Yesim
dc.contributor.authorYuksel, Rana
dc.contributor.authorYenin, Julide Zehra
dc.date.accessioned2024-09-18T19:52:38Z
dc.date.available2024-09-18T19:52:38Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: In this study, we aimed to evaluate total oxidative stress and total antioxidant capacity in serum samples from patients with Alopesia Areata (AA) in our laboratory conditions. Methods: In this study, 46 subjects with AA (26 females, 20 males) and the control subjects of 36 (20 females, 16 males) age-and sex-matched healthy volunteers from our hospital staffs were enrolled (the mean age was 23.7 +/- 11.0 years). Blood samples were obtained following an overnight fasting state, and were collected on ice at 4 degrees C. The serum samples were separated from the cells by centrifugation at 3000 rpm for 15 min and were stored at -80 degrees C and used for the analysis of the Total Antioxidant Status (TAS) and Total Oxidant Status (TOS). Results: Total Antioxidant Status (TAS) and Total Oxidant Status (TOS), Oxidative Stress Index (OSI) (TOS/TAS) levels of AA patients were 1.4777 +/- 0.1986; 9.7490 +/- 6.0445; 0.6593 +/- 0.4069 respectively. TAS; TOS; OSI (TOS/TAS) levels of controls were 1.4028 +/- 0.1687; 9.4627 +/- 4.2781; 0.6875 +/- 0.3232 respectively. TAS, TOS and OSI levels showed no significant difference between the control and AA group (p > 0.05). Conclusion: Future studies about AA pathogenesis should be based not only on oxidant/antioxidant balance but also on several other factors. Because it was observed that the disease showed recurrence in different situations. Since the selection criteria of patients is affected from disease severity and environmental and genetical factors, multicentric studies with better sampled patient population and higher patient number is required.en_US
dc.identifier.endpage1093en_US
dc.identifier.issn1940-5901
dc.identifier.issue4en_US
dc.identifier.pmid24955187en_US
dc.identifier.startpage1089en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7568
dc.identifier.volume7en_US
dc.identifier.wosWOS:000336740600040en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlopecia areata (AA)en_US
dc.subjectTASen_US
dc.subjectTOSen_US
dc.subjectOSIen_US
dc.subjectoxidative stressen_US
dc.titleEvaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areataen_US
dc.typeArticleen_US

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