CAFFEIC ACID PHENETHYL ESTER DECREASES THE LEVEL OF S-100B PROTEIN AFTER MIDDLE CEREBRAL AFTER OCCLUSION IN RABBITS

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dc.authoridBal, Ramazan/0000-0003-3829-8669
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorBal, Ramazan
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorKontas, Tuenay
dc.contributor.authorMelek, Ismet Murat
dc.date.accessioned2024-09-18T20:06:11Z
dc.date.available2024-09-18T20:06:11Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEffects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10 mu g/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.en_US
dc.identifier.endpage316en_US
dc.identifier.issn1011-601X
dc.identifier.issue3en_US
dc.identifier.pmid19553181en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8347
dc.identifier.volume22en_US
dc.identifier.wosWOS:000270501300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectCAPEen_US
dc.subjectexperimental strokeen_US
dc.subjectmiddle cerebral artery occlusionen_US
dc.subjectMCAen_US
dc.subjectS100Ben_US
dc.titleCAFFEIC ACID PHENETHYL ESTER DECREASES THE LEVEL OF S-100B PROTEIN AFTER MIDDLE CEREBRAL AFTER OCCLUSION IN RABBITSen_US
dc.typeArticleen_US

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