Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus

Basit Öğe Kaydı
dc.authoridOgeturk, Murat/0000-0002-5744-4812
dc.authoriddabak, durrin ozlem/0000-0001-7210-6873
dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.contributor.authorMeydan, Sedat
dc.contributor.authorKus, Ilter
dc.contributor.authorTas, Ufuk
dc.contributor.authorOgeturk, Murat
dc.contributor.authorSancakdar, Enver
dc.contributor.authorDabak, Durrin Ozlem
dc.contributor.authorZararsiz, Ismail
dc.date.accessioned2024-09-18T20:26:44Z
dc.date.available2024-09-18T20:26:44Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the morphological changes of the hippocampus after orchiectomy and the protective effects of testosterone on these changes. Animals were divided into 3 groups. The rats in group I were used for sham-orchiectomy. Orchiectomy was performed on the rats in group II. The rats in group III were administrated testosterone propionate 0.5 mg/kg/day for 30 days after the orchiectomy. Some of the hippocampal tissues were used for determination of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activities, and malondialdehyde (MDA) levels. The remaining hippocampal tissue specimens were stained with routine histological methods and examined under the light microscope. Additionally, the samples were immunohistochemically stained by using avidin-biotin-peroxidase for determination of bax immunoreactivity. The SOD and GSH-Px enzyme activities of the hippocampus were decreased, and MDA levels were increased in group II rats compared to the sham-orchiectomy group. In the light microscopic evaluation of the tissue specimens from group II, significant increases were detected in the number of picnotic cells and in bax immunoreactivity compared to the sham-orchiectomy group. However, an increase was observed in activities of SOD and GSH-Px enzymes and a decrease of the MDA levels in animals with orchiectomy, but having externally administered testosterone. It was determined that the increase of bax immunoreactivity and histopathological changes in this group were regressed by testosterone. The results of our study revealed that orchiectomy-induced oxidative damage and morphological changes in the hippocampal tissue were suppressed by testosterone. (C) 2010 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jchemneu.2010.07.006
dc.identifier.endpage285en_US
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.issue4en_US
dc.identifier.pmid20696235en_US
dc.identifier.scopus2-s2.0-78549254489en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2010.07.006
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10513
dc.identifier.volume40en_US
dc.identifier.wosWOS:000285322100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHippocampusen_US
dc.subjectTestosteroneen_US
dc.subjectOrchiectomyen_US
dc.subjectImmunohistochemistlyen_US
dc.subjectRaten_US
dc.titleEffects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampusen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
291.65 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu