Comparing the effects of fluticasone, anti-IgE and anti-TNF treatments in a chronic asthma model

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dc.authoridKUCUKOSMANOGLU, ERCAN/0000-0002-1824-2038
dc.contributor.authorOzkars, M. Y.
dc.contributor.authorKeskin, O.
dc.contributor.authorTokur, M.
dc.contributor.authorUlasli, M.
dc.contributor.authorGogebakan, B.
dc.contributor.authorCiralik, H.
dc.contributor.authorKucukosmanoglu, E.
dc.date.accessioned2024-09-18T19:54:31Z
dc.date.available2024-09-18T19:54:31Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Corticosteroids are used in the treatment of asthma. The aim of this study was to determine the efficacy of anti-IgE and anti-TNF alpha as asthma treatments. Methods: A mouse model of chronic asthma was developed. The fluticasone group was exposed to fluticasone and the anti-IgE and anti-TNF groups were administered anti-IgE or anti-TNF. IL-4, and IgE levels were measured, and histological analysis, pathological analysis and miRNA-126, miRNA-133a analyses were applied. Results: The cell concentration in the BAL fluid decreased in all the treatment groups. The rate of perivascular and peribronchial cell infiltration decreased in the lung in the high-dose anti-IgE and anti-TNF groups. Smooth muscle thickness decreased in the lung tissue in the low dose anti-IgE and anti-TNF groups. Bronchial wall thickness decreased in the lung tissue in the fluticasone + antidgE group. The IL-4 level in BAL fluid decreased in the high-dose anti-IgE, fluticasone + anti-IgE and anti-TNF groups. IgE levels increased in the BAL fluid in the high dose anti-IgE and anti-TNF groups. The lymphocyte level increased in the BAL fluid in the high-dose anti-IgE group. The macrophage level decreased in the BAL fluid in the anti-TNF group. The relative expression of miRNA-126 increased in all groups. The relative expression of miRNA-133a decreased in the placebo and fluticasone groups. The relative expression of miRNA133a increased in the low-dose anti-IgE, high-dose anti-IgE, fluticasone + anti-IgE and anti-TNF groups. Conclusions: The results showed that anti-IgE is successful as a treatment. Fluticasone + antiIgE and anti-TNF were seen to be superior to other therapeutic modalities when used for prophylaxis. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipGaziantep University Scientific Research Projectsen_US
dc.description.sponsorshipGaziantep University Scientific Research Projects.en_US
dc.identifier.doi10.1016/j.aller.2017.07.003
dc.identifier.endpage234en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue3en_US
dc.identifier.pmid29191361en_US
dc.identifier.scopus2-s2.0-85035191874en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2017.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7780
dc.identifier.volume46en_US
dc.identifier.wosWOS:000430786300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-IgEen_US
dc.subjectAnti-TNFen_US
dc.subjectAsthmaen_US
dc.subjectFluticasoneen_US
dc.subjectIgEen_US
dc.subjectIL-4en_US
dc.subjectLung histopathologyen_US
dc.subjectmiRNA-126en_US
dc.subjectmiRNA-133aen_US
dc.titleComparing the effects of fluticasone, anti-IgE and anti-TNF treatments in a chronic asthma modelen_US
dc.typeArticleen_US

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