Phytochemical Profiling and In Vitro Antioxidant, Antimicrobial, Cytotoxicity Effects of Some Glycyrrhiza Species from Turkey

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dc.contributor.authorKarahan, Faruk
dc.contributor.authorTuerkmen, Musa
dc.contributor.authorAvsar, Cumhur
dc.contributor.authorGezici, Sevgi
dc.date.accessioned2024-09-18T20:08:13Z
dc.date.available2024-09-18T20:08:13Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractGlycyrrhiza (licorice) species, known as the grandfather of herbs is one of the most popular medicinal plants used in traditional medicines and ethnobotany since ancient times. The present study aimed to determine the chemical composition, anti-cancer, antimicrobial and antioxidant activities of Glycyrrhiza glabra L., G. flavescens Boiss., and G. echinata L. taxa from different ecological conditions in Turkey. Root and leaf extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using the DPPH radical scavenging activity method. The antimicrobial analysis results show that Gram-negative bacteria are more sensitive to the extracts than Gram-positive, and antimicrobial values of the root extracts were also more effective than the leaf extracts. The antioxidant activities of the extracts varied from 4.2 to 2196 mu g/mL. Cytotoxicity activities of the Glycyrrhiza extracts were assessed in NCI-N87, LNCaP, and BxPC-3 human cancer cells, and the extracts exhibited remarkable activities towards the cells, with the IC50 value ranging from 16.28 +/- 1.08 to 171.04 +/- 0.68 mu g/mL. Moreover, the chemical contents of the extracts were analyzed, and toluene, phenol, palmitic acid, chroman, butyric acid and lidocaine were determined in both the roots and leaves of the extracts. In the present study, our results also revealed that ecological conditions might affect the chemical content and biological activities of the extracts. Overall, it was found that the tested Glycyrrhiza extracts could have rich sources of medicinal drugs and natural plant products in the future.en_US
dc.identifier.doi10.1007/s11094-024-03123-z
dc.identifier.endpage111en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85193569184en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-024-03123-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8716
dc.identifier.volume58en_US
dc.identifier.wosWOS:001228367100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchemical compositionen_US
dc.subjectcytotoxicityen_US
dc.subjectlicoriceen_US
dc.subjectmedicinal planten_US
dc.subjectnatural producten_US
dc.titlePhytochemical Profiling and In Vitro Antioxidant, Antimicrobial, Cytotoxicity Effects of Some Glycyrrhiza Species from Turkeyen_US
dc.typeArticleen_US

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