Evaluation of newly synthesized and commercially available charged cyclomaltooligosaccharides (cyclodextrins) for capillary electrokinetic chromatography

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dc.contributor.authorCulha, M
dc.contributor.authorSchell, FM
dc.contributor.authorFox, S
dc.contributor.authorGreen, T
dc.contributor.authorBetts, T
dc.contributor.authorSepaniak, MJ
dc.date.accessioned2024-09-18T20:26:41Z
dc.date.available2024-09-18T20:26:41Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA highly new charged cyclodextrin (CD) derivatives, (6-O-carboxymethyl-2,3-di-O-methyl)cyclomaltoheptaoses (CDM-beta-CDs), was synthesized and characterized as anionic reagents for capillary electrophoresis (CE) in an electrokinetic chromatography mode of separation. Substitution with dimethyl groups at the secondary hydroxyl sites of the CD is aimed at influencing the magnitude and selectivity of analyte-CD interactions, while substitution by carboxymethyl groups at the primary hydroxyl sites provides for high charge and electrophoretic mobility. Full regioselective methylation at the secondary hydroxyl sites was achieved in this work, while substitution at the primary hydroxyl sites generated a mixture of multiply charged products. The separation performance of CDM-beta-CD was evaluated using a variety of analyte mixtures. The results obtained from commercially available negatively charged cyclodextrins, heptakis(2,3-di-O-methyl-6-O-sulfo)cyclomaltoheptaose (HDMS-beta-CD) and O-(carboxymethyl)cyclomaltoheptaose (CM-beta-CD) with an average degree of substitution one (DS 1), were compared to CDM-beta-CD using a sample composed of eight positional isomers of dihydroxynaphthalene. Four hydroxylated polychlorobiphenyl derivatives, a group of chiral and isomeric catchecins, and chiral binaphthyl compounds were also separated with CDM-beta-CD. The effect of adding neutral beta-cyclodextrin (beta-CD) into the running buffer containing charged cyclodextrins was investigated and provided evidence of significant inter-CD interactions. Under certain running buffer conditions, the charged cyclodextrins also appear to adsorb to the capillary walls to various degrees (C) 2003 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.carres.2003.10.004
dc.identifier.endpage249en_US
dc.identifier.issn0008-6215
dc.identifier.issn1873-426X
dc.identifier.issue2en_US
dc.identifier.pmid14698882en_US
dc.identifier.scopus2-s2.0-0346786356en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1016/j.carres.2003.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10485
dc.identifier.volume339en_US
dc.identifier.wosWOS:000188118300008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectheptakis(6-O-carboxymethyl-2,3-di-O-methyl)cyclomaltoheptaoseen_US
dc.subjectneutral positional isomersen_US
dc.subjectcapillary electrophoresisen_US
dc.subjectchiral separationsen_US
dc.subjectcharacterizationen_US
dc.titleEvaluation of newly synthesized and commercially available charged cyclomaltooligosaccharides (cyclodextrins) for capillary electrokinetic chromatographyen_US
dc.typeArticleen_US

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