The protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats

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dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.authorid, ahmet/0000-0001-6274-5700
dc.contributor.authorMeydan, S.
dc.contributor.authorAltas, M.
dc.contributor.authorNacar, A.
dc.contributor.authorOzturk, O. H.
dc.contributor.authorTas, U.
dc.contributor.authorZararsiz, I.
dc.contributor.authorSarsilmaz, M.
dc.date.accessioned2024-09-18T20:52:53Z
dc.date.available2024-09-18T20:52:53Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Toluene is used as an organic solvent, and it has neurotoxic effects. Omega-3 is an essential fatty acid required for brain development. The aim of this study was to investigate the protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats. Materials and methods: A total of 21 male Wistar rats were divided into three groups with seven rats in each group. Rats in group I were the controls. Toluene was intraperitoneally injected into the rats of group II with a dose of 0.5 ml/kg. Rats in group III received omega-3 fatty acid with a dose of 0.4 g/kg/day while exposed to toluene. After 14 days, all the rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and the level of malondialdehyde (MDA) were spectrophotometrically studied in the prefrontal cortex of rats. Results: Enzymatic activities of SOD and GSH-Px were decreased, and MDA levels were significantly increased in rats treated with toluene compared with the controls. However, the increased SOD and decreased GSH-Px enzymatic activities and MDA levels were detected in the rats administered with omega-3 fatty acid while exposed to toluene. Conclusion: The results of this experimental study indicate that omega-3 fatty acid treatment can prevent toluene-induced neuronal damage in the prefrontal cortex of rats.en_US
dc.identifier.doi10.1177/0960327112457187
dc.identifier.endpage1185en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue11en_US
dc.identifier.pmid23079668en_US
dc.identifier.scopus2-s2.0-84869057309en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1179en_US
dc.identifier.urihttps://doi.org/10.1177/0960327112457187
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11470
dc.identifier.volume31en_US
dc.identifier.wosWOS:000310884800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOmega-3 fatty aciden_US
dc.subjecttolueneen_US
dc.subjectprefrontal cortexen_US
dc.subjectraten_US
dc.titleThe protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of ratsen_US
dc.typeArticleen_US

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