Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts

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dc.authoridTUNCTAN, BAHAR/0000-0003-3439-7803
dc.contributor.authorKucuk, Meral Urhan
dc.contributor.authorSucu, Nehir
dc.contributor.authorFirat, Seyhan Sahan
dc.contributor.authorAytacoglu, Barlas Naim
dc.contributor.authorVezir, Ozden
dc.contributor.authorBozali, Caner
dc.contributor.authorCanacankatan, Necmiye
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAngiotensin-converting enzyme (ACE) inhibitors block angiotensin II formation and release bradykinin, which is effective in the regulation of oxidoinflammatory injury. Some reports denote alterations in the effectiveness of ACE inhibitors in association with ACE insertion/deletion (I/D) gene polymorphisms. This study investigates the effects of ramipril on the oxidoinflammatory cytokines (IL-6, IL-8, TNF-alpha) and TnT (myocardial injury marker) and their alteration in association with ACE I/D gene polymorphisms. The study group (n = 51) patients received ramipril before coronary artery bypass grafting (CABG), while patients not receiving ramipril (n = 51) constituted the controls. TNF alpha, IL-6, and IL-8 were evaluated using ELISA and TnT by electrochemiluminescence methods before the induction of anesthesia (t1), at the 20th minute following cross-clamping (t2), at the end of the operation (t3), and at the 24th hour from the commencement of anesthesia (t4). Genotyping was performed by PCR. Differences between the groups were significant at t4 for the TNF alpha and at t3 for IL-6 (p < 0.05). The TnT levels increased from t2 onward in the control group and were highest in t3. Changes in t3 and t4 values in both groups according to their t1 values were significant (p < 0.05). However, differences between the groups were insignificant (p > 0.05). The IL-6, IL-8, TNF alpha, and TnT serum levels had no correlation with the ACE I/D gene polymorphism. Low cytokine and TnT levels in the study group, especially after cross-clamping, may indicate the protective effect of ramipril from oxidoinflammatory injury. This effect did not appear to be associated with the ACE I/D gene polymorphism.en_US
dc.description.sponsorshipMersin University Scientific Projects Unit [BAP-TF CTB (NS) 2009-3 A]en_US
dc.description.sponsorshipThis work has been supported by grants from the Mersin University Scientific Projects Unit (BAP-TF CTB (NS) 2009-3 A).en_US
dc.identifier.doi10.1007/s00228-014-1751-5
dc.identifier.endpage1451en_US
dc.identifier.issn0031-6970
dc.identifier.issn1432-1041
dc.identifier.issue12en_US
dc.identifier.pmid25256070en_US
dc.identifier.scopus2-s2.0-84921938109en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1443en_US
dc.identifier.urihttps://doi.org/10.1007/s00228-014-1751-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7310
dc.identifier.volume70en_US
dc.identifier.wosWOS:000345138700005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Journal of Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectACE geneen_US
dc.subjectACE inhibitorsen_US
dc.subjectRamiprilen_US
dc.subjectCoronary artery bypass graft (CABG)en_US
dc.titleRole of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass graftsen_US
dc.typeArticleen_US

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